논문 검색
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Comparative effects of pharmacological interventions in the prophylactic treatment of tension-type headache: systematic review and network meta-analysis.
TL;DRAmitriptyline 100 mg and BTX-A 100 U may be options to reduce monthly headache days in patients with chronic TTH given the low to very low certainty of evidence, high risk of bias, and high heterogeneity.
FULLTEXT: paradigm shift randomized randomized -
Comparative efficacy of intralesional therapies for keloid scars: a network meta-analysis.
TL;DRIt is indicated that combination therapies, most notably 5-FU’s+ corticoids’+ YAG:Laser, offer the greatest benefit, and data for novel agents suggest potential, while data for novel agents suggest potential.
FULLTEXT: paradigm shift randomized randomized -
A prospective study of hair transplantation combined with concentrated growth factors for the treatment of androgenetic alopecia.
TL;DRCGF-assisted FUE significantly improved hair density and terminal hair ratio compared with FUE alone, with favorable safety and high patient satisfaction.
FULLTEXT: paradigm shift randomized randomized -
Chondrocyte proliferation without inflammation underlies botulinum toxin-induced mandibular enthesis bone hypertrophy in rats.
TL;DRBTX-related muscle atrophy of masticatory muscle induced chondrocyte proliferation at enthesis without inflammation process and BTX-related muscle atrophy of masticatory muscle induced chondrocyte proliferation at enthes…
FULLTEXT: paradigm shift randomized randomized -
Intra-articular therapies for synovial joint dysfunction: a comprehensive integrative review.
TL;DRIntra-articular therapy has advanced from palliation to mechanism-driven modulation and i-PRF and mesenchymal stem cells show the strongest disease-modifying signals; HA remains a safe backbone and carrier.
FULLTEXT: paradigm shift randomized randomized -
Electromyography-guided botulinum toxin injections in provoked vestibulodynia: a randomized double-blind placebo-controlled clinical trial.
TL;DROnabotulinum toxin A injections were effective on the pain, quality of life and sexual functions of the patients and it is suggested that muscular dysfunction is a key element of vestibulodynia pain.
FULLTEXT: paradigm shift randomized randomized -
Evaluation of the ultrasonography-guidance for botulinum toxin type a injection into lateral pterygoid muscle in patients with TMJ anterior disc displacement with reduction.
TL;DRThe findings suggest that ultrasound-guided BTX-A injection into the LPM is a safe and effective treatment for ADDwR, enhancing joint function and symptom relief, although larger randomized studies are recommended.
FULLTEXT: paradigm shift randomized randomized -
From Palliation After Angiosarcoma Resection to Totally Autologous Aesthetic Breast Reconstruction Combining Kiss Latissimus Dorsi Flap and Contralateral Breast Sharing Internal Mammary Artery Perforator Flap: A Case Report.
Angiosarcoma of the breast is a rare but aggressive disease that often requires wide-margin resection resulting in massive thoracic defects. In this report we present the unique case of a patient who underwent primary chest wall reconstruct…
FULLTEXT: paradigm shift randomized randomized -
Red and near-infrared photobiomodulation for burn, hypertrophic, and post-surgical scars: a scoping review of clinical trials.
[PURPOSE] Scars may lead to pain, pruritus, functional impairment, and cosmetic concern despite standard therapies. Photobiomodulation (PBM) delivered by light-emitting-diode (LED) or low-level laser therapy (LLLT) has emerged as a non-inva…
FULLTEXT: paradigm shift randomized randomized -
Effect of Botulinum Toxin Injection Intervals on the Irreversibility of Targeted Muscle Paralysis: An Electromyographic Study.
[BACKGROUND] Botulinum neurotoxin A (BoNT-A) is widely used clinically, yet its temporary effects require repeated injections that increase cost and inconvenience. Claims that repeated BoNT-A use alters efficacy lack rigorous evaluation. Un…
FULLTEXT: paradigm shift randomized randomized -
Piezoelectric Versus Conventional Rhinoplasty: A GRADE-assessed Systematic Review and Meta-analysis of Randomized Controlled Trials.
Piezoelectric osteotomy may reduce postoperative morbidity after rhinoplasty, but time-based effects remain uncertain. We aimed to understand the time-based effectiveness and safety of piezoelectric osteotomy versus conventional method. We …
FULLTEXT: paradigm shift randomized randomized -
A systematic review of clinical evidence on the efficacy and safety of conditioned media, platelet-rich fibrin, stromal vascular fraction, extracellular vesicles, and stem cells in androgenetic alopecia.
[AIMS AND OBJECTIVES] Androgenetic alopecia (AGA) is a common progressive hair loss disorder caused by follicular miniaturization and shortened anagen phases. Conventional treatments mainly target androgen pathways but often yield unsatisfa…
FULLTEXT: paradigm shift randomized randomized -
Comparison of Polydioxanone and Polypropylene Sutures in Columellar Incision Closure: A Prospective Randomized Clinical Trial.
[BACKGROUND] Columellar scarring remains an important aesthetic concern in open septorhinoplasty, and while multiple studies have compared absorbable and non-absorbable sutures, the specific effects of slowly absorbable polydioxanone (PDS) …
FULLTEXT: paradigm shift randomized randomized -
Streamlined Facial Rejuvenation: A Randomized Split-Face Trial of Premixed Intradermal Botulinum Toxin Type A and Hyaluronic Acid Biorevitalization.
TL;DRPremixed intradermal BoNT-A with NCTF 135HA achieved superior wrinkle reduction, enhanced skin quality, and greater patient satisfaction than BoNT-A alone, with minimal downtime and an excellent safety profile.
FULLTEXT: paradigm shift randomized randomized -
Botulinum Toxin Type A in the Treatment of Primary Axillary Hyperhidrosis:A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Efficacy and Safety in Chinese Patients.
TL;DROne intradermal 50-U BoNTA treatment led to a significant reduction in axillary sweat weight, axillary hyperhidrotic area, HDSS scores, and axillary bromhidrosis grades in Chinese PAH patients, with a favorable safety pr…
FULLTEXT: paradigm shift randomized randomized -
Safety and Effectiveness of Two High-G' Soft Tissue Fillers for Chin Augmentation: A Prospective, Randomized, Comparator-Controlled, Evaluator-Blinded Trial.
TL;DRTo compare the safety and effectiveness of HASHA versus HAVLX for chin augmentation and correction of chin retrusion, a prospective, randomized, comparator-controlled, evaluator-blinded trial was conducted.
FULLTEXT: paradigm shift randomized randomized -
Effectiveness and Safety of a Polyvinyl Alcohol Microsphere and Hyaluronic Acid Suspension for Chin Augmentation: A Randomized Controlled Trial and Multidisciplinary Study.
TL;DRThe novel PVA-HA filler demonstrates favorable physicochemical and biocompatibility properties, and provides clinically significant and safe outcomes in chin augmentation, representing a promising new option for soft tis…
FULLTEXT: paradigm shift randomized randomized -
Preoperative GLP-1 Receptor Agonists and Thromboinflammatory Markers in Patients Undergoing Abdominoplasty: A Prospective Monocentric Study.
[BACKGROUND] Abdominoplasty in patients with obesity carries a heightened risk of venous thromboembolism (VTE) due to a proinflammatory and hypercoagulable baseline. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly use…
FULLTEXT: paradigm shift randomized randomized -
Histologic Evaluation of Piezotome and Traditional Osteotomy Techniques in Posterior Maxillary Rhinoplasty.
Rhinoplasty is the fifth most commonly performed cosmetic surgery globally. While surgical techniques used for rhinoplasty have evolved significantly in the past century, the creation of precise osteotomies remains a cornerstone of the proc…
FULLTEXT: paradigm shift randomized randomized -
Comparing patient satisfaction and pain control between vibration and topical anesthesia during botulinum toxin A injections: a randomized, double-blind, split-face clinical trial.
This study aimed to evaluate pain levels, patient satisfaction, and preferences for different anesthetic techniques during the cosmetic application of botulinum toxin A in the upper third of the face. A randomized, double-blind, split-face …
FULLTEXT: paradigm shift randomized randomized