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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, arising in diverse upper airway mucosal niches, is particularly aggressive, with poor 5-y survival and a limited response to immune…

Diffuse large B-cell Lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma for which current therapeutic strategies remain insufficient, in part owing to heterogeneity in tumor biology and the immune microenvironment. The…

[OBJECTIVES] Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are closely related hematologic malignancies. However, the transcriptomic distinctions between them are not fully elucidated. This study aimed to identify transcri…

Early and reliable detection of subcentimeter pulmonary nodules remains a major bottleneck in low-dose CT-based lung cancer screening due to high miss rates, vascular-adhesion-induced false positives, and insufficient multi-scale feature fu…

Immune escape mechanisms critically restrict the efficacy of immunotherapy in lung cancer (LC), with only 20%-30% of patients responding to checkpoint inhibitors. To systematically map global trends and identify emerging hotspots, this stud…

[PURPOSE] Microscopy-based cancer cell classification traditionally relies on cell-based morphological features, while subcellular organelle organization remains underutilized. Existing machine learning methods often require manual preproce…

[AIMS] The rapid development of therapies linked to molecular biomarkers has increased the importance of next-generation sequencing (NGS)-based tumor profiling to guide treatment decisions. Technology has enabled more comprehensive clinical…

[INTRODUCTION] Cancer cell proliferation occurs within the context of persistent genomic instability. In this review, we propose the RS-CCD-CIN axis as a systems-level framework in which replication stress (RS), cell cycle deregulation (CCD…

Sensitive and efficient detection of tumor-related mRNA is essential for the early diagnosis of cancer yet remains challenging due to low biomarker abundance and methodological limitations. Here, we developed a three-dimensional DNA nanomac…

[ETHNOPHARMACOLOGICAL RELEVANCE] Helicobacter pylori (H. pylori) infection represents the most significant pathogenetic factor for chronic gastritis (CG) and is also the most critical controllable risk factor for the prevention of gastric c…

[BACKGROUND] The role of 5-methylcytosine (m5C) RNA modification in clear cell renal cell carcinoma (ccRCC) is recognized, yet its function and regulation on circular RNAs (circRNAs) remain uncharted. This study aims to identify key m5C reg…

Myeloid leukemia is a malignant hematologic disorder characterized by abnormal proliferation and differentiation arrest of myeloid progenitor cells, and its molecular mechanisms remain incompletely understood. Protein 4.1R (EPB41) is a cyto…

Helicobacter pylori (H. pylori) infection is a major risk factor for gastric cancer (GC), but the molecular mechanisms driving H. pylori-induced gastric carcinogenesis remain incompletely understood. This study investigates the role of the …

[OBJECTIVE] To develop and validate a robust, multimodal machine learning framework integrating radiomic and deep learning features from multiplex immunohistochemistry (mIHC) images for comprehensive outcome prediction in colorectal cancer …

Colorectal cancer (CRC) typically follows the "normal-adenoma-carcinoma" (NAC) progression, with approximately 70-90% of cases driven by an adenomatous polyposis coli (APC) mutation-dependent pathway. The Apc-mutant (Min) mouse, valuable fo…

Tertiary lymphoid structures (TLSs) have emerged as key regulators of anti-tumor immunity and biomarkers for immunotherapy response in liver cancer, including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and combi…

Metastasis is the primary cause of cancer mortality, a complex cascade driven by intertwined cellular adaptability and microenvironmental reprogramming. Although its mechanistic origins are multifactorial and context-dependent, metabolic pl…

Liver cancer remains one of the leading causes of cancer-related death worldwide, and its immunologically "cold" tumor microenvironment continues to undermine the efficacy of immunotherapy. Among the many stroma-derived factors, C-X-C motif…

[BACKGROUND] Pancreatic ductal adenocarcinoma (PDAC) is characterized by frequent SMAD4 inactivation and extensive lipid metabolic rewiring, yet the mechanistic crosstalk between these processes remains poorly elucidated. [METHODS] Multi-o…

[BACKGROUND] Quercetin (QUR) exhibits multiple pharmacological activities against hepatocellular carcinoma (HCC). Competing endogenous RNA (ceRNA) networks and transcription factors (TFs) play critical roles in oncogenesis and cancer progre…