논문 검색

Lung cancer remains one of the leading causes of cancer-related deaths worldwide, highlighting the urgent need for accurate and interpretable diagnostic tools. While deep learning (DL) models have achieved strong results in medical image cl…

Primary central nervous system (CNS) neuroblastoma, FOXR2-activated (CNS-NB-FOXR2), is a rare embryonal tumor characterized by neuroblastic differentiation and structural rearrangement of the FOXR2 gene. Previously grouped under CNS primiti…

Pancreatic neuroendocrine tumors (PNETs) are relatively rare and highly heterogeneous tumors. Early diagnosis is a critical step in improving patient prognosis, but there is still a lack of circulating biomarkers with both high specificity …

Pancreatic neuroendocrine tumors (pNETs) exhibit substantial clinical and molecular heterogeneity. Using bulk and single-nucleus RNA sequencing, we identify five molecular subtypes: Hedgehog-high, Alpha-like, Hypoxia-high, Gastrin-high, and…

[BACKGROUND] The management of pancreatic tumors varies depending on the tissue origin, as the tissue type results in numerous differences in the tumor's behavior. Pancreatic neuroendocrine tumors (pNETs) arise from pancreatic islet cells, …

Pancreatic neuroendocrine tumors (pNETs) are rare, clinically heterogeneous neoplasms with rising incidence linked to improved diagnostics. This review examines pNET management, addressing epidemiology, classification, diagnosis, treatment,…

[BACKGROUND] PRRT showed promising potential in the management of patients with pNETs. However, there is still a lack of evidence on its relative efficacy and safety compared with other treatment options. This review aims to synthesize the …

[BACKGROUND] Intraoperative localization of pancreatic neuroendocrine tumors (pNETs) is challenging, particularly for small lesions during minimally invasive surgery due to the lack of tactile feedback. Indocyanine green (ICG) fluorescence …

Herein, we have provided select updates targeted towards practicing pathologists pertaining to the pathology of kidney, testis, and penile cancer. This includes discussion of diagnostic criteria, evolution of nomenclature, emerging immunohi…

[BACKGROUND] With regard to laparoscopic approach, the objective arises whether standard multiorgan Whipple resection (PD) or parenchyma-sparing procedures (DPPHRt) are the most qualified surgical treatments for benign, premalignant neoplas…

[INTRODUCTION] Renal primitive neuroectodermal tumour (rPNET) is a rare entity, typically affecting young adults. The diagnosis is usually confirmed through histopathology. A multidisciplinary approach to treatment is essential due to its p…

[PURPOSE] Cabozantinib, a multi-kinase inhibitor, improves progression-free survival (PFS) in patients with advanced extrapancreatic neuroendocrine tumors (epNET). Cabozantinib alters the tumor microenvironment to be more permissive to immu…

Accurate and automatic registration of the pancreas between contrast-enhanced CT (CECT) and non-contrast CT (NCCT) images is crucial for diagnosing and treating pancreatic cancer. However, existing deep learning-based methods remain limited…

[INTRODUCTION] PNETs are rare pancreatic malignancies originating from islet cells and exhibit a strong co-occurrence with Diabetes Mellitus (DM), associated with worse survival outcomes. However, studies have yet to delineate the impact of…

Radiomics is a growing field for diagnosis, prognostication, and therapeutic decision-making in numerous solid tumors. Despite current promising findings in pancreatic neuroendocrine tumors (PNETs), significant limitations persist, includin…

Autophagy, a key lysosomal degradation pathway regulating metabolic adaptation in cancer, plays fundamental roles in both the tumor and host stromal compartments during cancer progression. An important unanswered question is whether and how…

[BACKGROUND] Pancreatic cancer is a common and lethal malignancy, with the two primary subtypes being pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumors (pNET). Accurate diagnosis and effective treatment are crucia…

[INTRODUCTION] Lung cancer remains the leading cause of cancer-related mortality. Although bronchoscopy allows direct visualization and tissue sampling, detecting subtle lesions is still challenging owing to limited resolution, variable ima…

Rising global cancer rates are projected to significantly increase by 2050, highlighting the urgent need for improved scalable prevention, early detection, and personalized therapy tools. Artificial intelligence (AI) has demonstrated signif…

[BACKGROUND] Pancreatic acinar cell carcinoma (ACC) is a rare primary neoplasm of acinar cell origin. Histologically, it can present as pure ACC or mixed with neuroendocrine or ductal differentiation. We studied whether ACC shared genomic s…