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Multimerization approach to improve a cell surface plectin binding cancer stem cell targeted peptoid drug‑lead.
TL;DRThe highly specific and selective cytotoxic effects of PCS2T3.9 on STP-enriched CSCs offer a significant therapeutic advantage by potentially minimizing off-target effects on normal tissues, establishing this peptoid as …
FULLTEXT: Multimerization -
Structural basis for sialoglycan recognition by the immune inhibitory receptor Siglec-10.
Sialic acid-binding immunoglobulin-like lectin 10 (Siglec-10) inhibits immune cell function by sensing the presence of sialylated glycoproteins. Here, we determined structures of Siglec-10 bound to sialyllactose (SL) ligands to visualize th…
FULLTEXT: Multimerization -
Zinc-mediated multimerization of the N-terminal CCHC zinc finger domain of BCL11B: a key to stability and a potential therapeutic target.
The transcription factor B cell lymphoma/leukemia 11B (BCL11B) homomultimerizes its N-terminal CCHC-type zinc finger domain. Our previous findings revealed that BCL11B forms tetramers, rather than the initially predicted dimers. This requi…
FULLTEXT: Multimerization -
Phosphatidylinositol phospholipids drive hepatitis C virus core protein assembly on lipid membranes.
Hepatitis C virus (HCV) genome codes for various proteins essential to its replication cycle. Among these, the core protein (HCC) forms the capsid via organized multimerization, thereby guiding viral assembly. This process depends on the dy…
FULLTEXT: Multimerization -
High-resolution analysis of the human T-cell leukemia virus capsid protein reveals insights into immature particle morphology.
Infection with human T-cell leukemia virus type 1 (HTLV-1) can result in adult T-cell leukemia/lymphoma and HTLV-1 associated-myelopathy/tropical spastic paraparesis. The Gag polyprotein - the major structural protein - is crucial for drivi…
FULLTEXT: Multimerization -
Inhibitory Effect of Fucoidan Analogs on Highly Metastatic Gastric Cancer Cells via Galectin-4 Inhibition.
In malignant-type gastric cancer, peritoneal dissemination is the most frequent metastatic process and is an inoperable condition for which effective treatment is lacking. Our research has revealed that galectin-4 plays an important role in…
FULLTEXT: Multimerization -
Preclinical Evaluation and First-in-Human Study of [Ga]Ga-αvβ6-2: A Novel Dimeric Integrin αvβ6-Targeted PET Probe for Pancreatic Cancer Imaging.
Integrin αvβ6 is highly expressed in pancreatic cancer, making it an ideal target for molecular imaging diagnosis. Multimerization is considered an effective strategy to increase the accumulation of molecular probes in tumors. Here, we synt…
FULLTEXT: Multimerization -
Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy.
T-cell lymphomas (TCLs) are heterogeneous malignancies with limited treatment options and poor outcomes. The efficacy of traditional T-cell therapies, including chimeric antigen receptor (CAR) T cells, is often constrained by immunosuppress…
FULLTEXT: Multimerization