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Prostate Cancer Care for Men with an Intellectual Disability: A Population-based Cohort Study of Symptoms, Diagnosis, Treatment, and Survival.
[BACKGROUND AND OBJECTIVE] Intellectual disability (ID) is increasingly recognised as a hidden driver of cancer mortality. However, evidence on prostate cancer (PC) care in this population is limited. [METHODS] The study population compris…
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Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, arising in diverse upper airway mucosal niches, is particularly aggressive, with poor 5-y survival and a limited response to immune…
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NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells.
Bispecific antibodies are used for the treatment of hematological malignancies as well as solid tumors. One of their main effector mechanisms is the recruitment of effector cells such as CD8 T cells and CD16A NK cells to tumor cells. Bispec…
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Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunity.
T-cell exhaustion is a state of functional decline in T cells, driven by chronic antigen exposure and inhibitory signals within the tumor microenvironment. Exhausted CD8+ T cells (Tex) derive from precursor exhausted T cells (Tpex), a self-…
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Gene-level gut microbiome signatures as predictive biomarkers for response to immune checkpoint inhibitors across multiple cancer types.
Targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with immune checkpoint inhibitors (ICIs) has improved survival across multiple cancer types, but the variability in patient response h…
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Trends and projections of Burkitt Lymphoma burden (1990-2036): an analysis based on the global burden of disease study 2021.
[OBJECTIVES] The aim of this study was to assess the burden of Burkitt lymphoma (BL) at the global, regional, and national levels from 1990-2021 and to project trends over the next 15 years. [METHODS] Data from the 2021 Global Burden of Di…
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VGLL4 regulates the Wnt/β-catenin signaling pathway and acts as an oncogenic factor in acute myeloid leukemia.
[OBJECTIVE] To investigate the expression, function, and underlying mechanism of VGLL4 in AML. [METHODS] Bioinformatic analysis of TCGA data by GEPIA website was performed. VGLL4 protein expression was analyzed by Western blot. We then per…
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Real-world efficacy of Bruton tyrosine kinase inhibitor based maintenance therapy in diffuse large B-cell lymphoma: a multicenter retrospective cohort study with external historical control.
[INTRODUCTION] The selection of an optimal maintenance agent in diffuse large B-cell lymphoma (DLBCL) continues to pose a significant clinical challenge. This study aims to evaluate the prognostic impact of maintenance therapy (MT) in DLBCL…
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UCHL5 suppresses thyroid carcinoma progression via ZRANB1 stabilization and ferroptosis regulation.
[OBJECTIVE] This study investigated the role of UCHL5 in thyroid carcinoma (THCA) progression, focusing on its tumor-suppressive mechanisms and regulation of ferroptosis. [METHODS] We performed multi-omics analysis of TCGA and GEO datasets…
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Exploring the key functions of T cells and the regulation of the immune microenvironment in prostate cancer using single-cell RNA sequencing and bulk RNA sequencing.
The incidence of prostate cancer continues to increase, making it the second most common malignant tumor among men worldwide. Immunotherapy has emerged as a key therapeutic strategy for treating tumors. Numerous studies have established tha…
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Genetic relationships between the gut microbiota and prostate cancer: Mendelian randomization combined with bioinformatics analysis.
[BACKGROUND] Prostate cancer (PCa) is a leading cause of male cancer-related death globally. While the gut microbiota is linked to PCa, its genetic association remains unclear. [METHODS] We screened genetic instruments related to the gut m…
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Development and validation of machine learning prognostic models for overall survival in non-surgical prostate cancer patients with bone metastases.
[OBJECTIVE] To construct and interpret a machine learning model for predicting overall survival in nonsurgical prostate cancer with bone metastases (PCBM). [METHODS] Data from 3,378 SEER database patients were utilized to develop machine l…
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Harsh parenting and rs11621961 at the locus: gene-environment interaction effects on hair cortisol in a Brazilian population-based longitudinal study.
Hair cortisol concentration (HCC) reflects long-term hypothalamic-pituitary-adrenal (HPA) axis activity and is a biomarker of chronic stress. Although HCC has been linked to mental health, less is known about how genetic susceptibility and …
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metaFun: An analysis pipeline for metagenomic big data with fast and unified functional searches.
Metagenomic approaches offer unprecedented opportunities to characterize microbial community structure and function, yet several challenges remain unresolved. Inconsistent genome quality impairs reliability of metagenome-assembled genomes, …
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A dual diacylglycerol kinase (DGK) alpha/zeta inhibitor augments the activity of human tumor infiltrating lymphocytes in and models.
Endogenous or adoptively transferred tumor-infiltrating lymphocytes (TILs) often lose their functional capacity due to the activation of intrinsic inhibitory pathways, which then limits their ability to control tumor growth. In this study, …
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A mixed inflammatory peripheral signature defines clinical outcomes in a phase II trial combining pembrolizumab with paclitaxel and carboplatin in melanoma.
Checkpoint blockade of PD-1 with pembrolizumab provides long-term survival to a significant proportion of patients with metastatic melanoma. Pembrolizumab has been successfully used in combination with chemotherapy in non-small-cell lung ca…
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Breast cancer patients in Saudi Arabia experienced intimate partner violence.
Breast cancer is the most common type of cancer among Saudi women. Despite this prominence, the lack of data on the association between intimate partner violence (IPV) and breast cancer among Saudi women has presented significant obstacles …
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Assessment of risk factors of breast cancer among women in Dodoma, Tanzania: a community-based cross-sectional study.
Assessment of risk factors of breast cancer in the general population provides insightful information towards prevention of breast cancer. This study aimed to assess the risk factors of breast cancer among women in a community from a resour…
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Early local immune activation following intra-operative radiotherapy in human breast tissue.
The local immune effects of cancer radiotherapy remain poorly characterized in humans due to limited access to irradiated tissue. Mechanistic insights largely derive from preclinical models employing tumor-intact, neoadjuvant-like settings.…
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Trial Watch - bispecific T cell engagers and higher-order multispecific immunotherapeutics.
Over the past decades, cancer immunotherapy has evolved into clinical practice, with bispecific T cell engagers (TCEs) and other higher-order multispecific immunotherapeutics emerging as approaches for precision immune modulation. These eng…
FULLTEXT: Data processing