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Poly(ADP-ribose) polymerase (PARP) inhibitors constitute a significant class of targeted anticancer therapies that leverage the principle of synthetic lethality in tumours deficient in homologous recombination (HR) repair. Although these ag…

[BACKGROUND] PD-1 and LAG-3 are immune checkpoint molecules frequently co-expressed in the tumor microenvironment, where they synergistically drive T-cell exhaustion and immune escape. Dual blockade of these pathways represents a promising …

TL;DR3D simulation enhances patient engagement and expectation management across various aesthetic procedures and serves as a complementary tool rather than a definitive factor in decision-making.

[BACKGROUND] Real-world data (RWD) from electronic medical records (EMRs) is increasingly utilized in oncology to complement evidence from clinical trials by reflecting routine clinical practice and diverse patient populations. However, man…

Colorectal cancer (CRC) is a highly heterogeneous malignancy that is divided into four consensus molecular subtypes (CMSs), with CMS4 considered to be the worst type of CRC. The CMS classification has not been translated into clinical pract…

Cold atmospheric plasma (CAP) has emerged as a promising non-thermal modality in cancer research due to its ability to induce selective cytotoxicity through reactive oxygen and nitrogen species. However, the limited penetration depth and in…

Triple-negative breast cancer (TNBC) remains one of the most aggressive breast cancer subtypes due to its high metastatic potential, poor response to conventional therapies, and frequent relapse after chemotherapy. In this work, we report a…

Prostate cancer (PCa) is the second most common malignancy in men and represents about 7% of newly diagnosed tumors worldwide (and up to 15% in developed countries). At the genomic level, PCa is generally characterized by copy number altera…

Chronic liver fibrosis is a progressive and globally prevalent pathological condition that poses a substantial threat to human health, frequently culminating in cirrhosis and hepatocellular carcinoma (HCC). A range of etiological factors, i…

Anaplastic lymphoma kinase (ALK) is a clinically validated oncogenic driver in multiple malignancies; however, the long-term efficacy of ALK tyrosine kinase inhibitors is frequently compromised by tumor heterogeneity, adaptive signaling, an…

Aggregation-induced emission (AIE) probes have attracted considerable interest in bioanalysis because of their good photostability, high imaging contrast, and longtime tracing capability. Herein, we developed a new AIE-active probe, AIE-BC,…

In the current medical era, developing multi-target anticancer agents that simultaneously engage complementary cellular vulnerabilities represents a promising strategy to overcome the inherent limitations of single-target therapeutics. Buil…

TL;DRRadiofrequency ablation is supported as a safe and effective therapy that can play a complementary role to surgery and radioactive iodine in the management of nodal recurrence of PTC.

[BACKGROUND] Prognostic biomarker panels identified through bulk sequencing approaches have shown utility in localized prostate cancer but are limited by underlying molecular heterogeneity. Spatial transcriptomics offers a complementary app…

TL;DRGAST-NET demonstrated strong generalizability and potential clinical utility in predicting perineural invasion (PNI) and prognosis in gastric cancer and when used as a decision-support tool, GAST-NET significantly improv…

TL;DRVNC images demonstrate superior lipiodol removal efficacy and beam-hardening artifacts reduction, facilitating precise RVT delineation and TACE-induced necrosis assessment, complementing contrast-enhanced CT for TACE eff…

TL;DRIts dual role highlights ERMP1 as a promising diagnostic and prognostic biomarker in MASLD-related HCC and plays a protective role in MASLD and β-catenin-driven HCC by modulating lipid metabolism, but may support tumor p…

Antibody-drug conjugates (ADCs), bispecific T-cell engagers (TCEs), and chimeric antigen receptor (CAR)-T cells require truly tumor-restricted surface antigens to minimize on-target/off-tumor toxicity. To identify such antigens, we interrog…

A novel, label-free electrochemical biosensor was precise engineered for the ultrasensitive and selective detection of miRNA-122, a pivotal biomarker in breast cancer diagnostics. This innovative sensing platform harnesses the exceptional c…

[BACKGROUND] Micro-ultrasound (micro-US; 29-MHz) offers real-time, high-resolution prostate imaging, but its stand-alone diagnostic accuracy remains uncertain. We synthesized prospective evidence to evaluate micro-US for classifying clinica…