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Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study).
[PURPOSE] For clinical (c) T1N0M0 rectal adenocarcinoma without adverse pathological features, local excision by transanal endoscopic surgery (TEM) is standard; however, contemporary series still report local recurrence (LR) rates of 15-20%…
FULLTEXT: Cellular Reprogramming randomized randomized -
Extended Transoral Resection of Anterior Commissure Tumors in a Canine Model: Impact on Laryngeal Framework, Glottis, and Vocal Function.
[BACKGROUND AND OBJECTIVES] Evaluate the feasibility and functional outcomes of extended transoral resection for anterior commissure (AC) tumors in canines, focusing on laryngeal framework, airway, and vocal function. [METHODS] Twelve dogs…
FULLTEXT: Cellular Reprogramming randomized randomized -
Transoral robotic surgery in head and neck cancer: an umbrella review of meta-analyses.
TL;DRThere are few studies on head and neck tumors other than oropharyngeal cancer, and there is a lack of studies on specific tumor stages or HPV status of the population, which does not allow for the provision of personaliz…
FULLTEXT: Cellular Reprogramming randomized randomized -
The results of randomized controlled trial comparing effectiveness of transanal endoscopic microsurgery versus endoscopic submucosal dissection.
TL;DRTEM resulted in a higher R0 and en bloc resection rate comparing to ESD and no difference in the recurrence rate was demonstrated; no difference in the recurrence rate was demonstrated.
FULLTEXT: Cellular Reprogramming randomized randomized -
Efficacy and Safety of Sphenopalatine Ganglion Block Versus Infraorbital and Infratrochlear Nerve Blocks in Nasal and Sinus Surgeries: A Systematic Review and Network Meta-Analysis.
TL;DRWhile both techniques effectively improve perioperative outcomes, SPGB appears superior for pain control and surgical field quality, especially in the endoscopic and functional endoscopic sinus surgery procedures, wherea…
FULLTEXT: Cellular Reprogramming randomized randomized -
Route Matters: Topically Applied Versus Locally Injected Tranexamic Acid for the Reduction of Post-rhinoplasty Edema and Ecchymosis.
TL;DRCompared with locally injected TXA, topically applied TXA administered immediately after osteotomy achieved greater early reduction in postoperative periorbital edema and ecchymosis, underscore the importance of the admi…
FULLTEXT: Cellular Reprogramming randomized randomized -
Botulinum Toxin Combined with Robot-Assisted Therapy for Post-Stroke Spasticity: A Systematic Review.
TL;DRThe combination of BoNT-A with RAT appears safe and is particularly promising for gait rehabilitation, but further research is needed to define optimal timing and protocols.
FULLTEXT: Cellular Reprogramming randomized randomized -
Short-term and Long-term Efficacy of Gastric Peroral Endoscopic Myotomy for Refractory Gastroparesis: A Meta-analysis.
TL;DRG-POEM may offer sustained symptoms and gastric emptying improvement in refractory GP, but findings should be interpreted cautiously given reliance on observational data, variable success definitions, lack of sham-contro…
FULLTEXT: Cellular Reprogramming randomized randomized -
Botulinum Toxin Injection in Retrograde Cricopharyngeal Dysfunction: A Meta-Analysis.
TL;DRThe efficacy, safety, and optimization of BonT‐A injections for RCPD are quantitatively summarized.
FULLTEXT: Cellular Reprogramming randomized randomized -
Intraoperative botulinum toxin injection in sleeve gastrectomy, a pilot randomized controlled trial.
TL;DRIntraoperative BP during SG is safe but does not improve peri-operative outcomes or patient-reported PONV when compared to standard ERAS measures, and administering botulinum toxin preoperatively during endoscopy may be …
FULLTEXT: Cellular Reprogramming randomized randomized -
Botulinum toxin A combining with robot-assisted bimanual therapy integrating mirror therapy versus botulinum toxin A combining with robot-assisted bimanual therapy in patients with post-stroke spastic fingers: a randomized controlled pilot trial.
TL;DRThe pilot data demonstrated that an adjunct to BoNT-A for post-stroke spastic fingers, RBMT may provide more benefit in distal UE function than did RBT, however, a larger sample size and adding a proper control group are…
FULLTEXT: Cellular Reprogramming randomized randomized -
Trans-axillary breast augmentation: a Randomized Controlled Trial comparing a new semi-endoscopic video-assisted technique versus the blind technique.
TL;DRA randomized trial comparing the trans-axillary blind approach with the new "semi-endoscopic" video-assisted trans-axillary approach for breast augmentation highlights how the endoscopic assistance could significantly he…
FULLTEXT: Cellular Reprogramming randomized randomized -
Is Endoscopic Submucosal Dissection Truly Comparable to Transanal Endoscopic Microsurgery for Early Rectal Epithelial and Subepithelial Tumors? A Meta-Analysis.
TL;DRThis study suggests that ESD is associated with a lower R0 resection rate compared to TEM, but offers a shorter mean LOS and procedural time.
FULLTEXT: Cellular Reprogramming randomized randomized -
Effects of photobiomodulation with 940 Nm diode laser on post-rhinoplasty nasal tip swelling: A randomized controlled trial.
TL;DRFindings suggest 940 nm PBM may accelerate resolution of post-rhinoplasty swelling through anti-inflammatory mechanisms, warranting further investigation in larger cohorts.
FULLTEXT: Cellular Reprogramming randomized randomized -
Effectiveness and Safety of Topically Applied Tranexamic Acid with Epinephrine in Surgical Procedures: A Systematic Review.
TL;DRThe combination of TXA and epinephrine appears safe and maybe effective for perioperative bleeding control, however, heterogeneity in dosing and outcomes limits generalizability.
FULLTEXT: Cellular Reprogramming randomized randomized -
Direct-to-implant breast reconstruction in prepectoral versus subpectoral planes: a meta-analysis framework for comparing complication rates and patient-reported outcomes.
TL;DRThis study aims to synthesize the current evidence comparing PP and SP in DTI breast reconstruction to inform surgical decision-making and optimize patient outcomes and will provide surgeons and patients with a clearer u…
FULLTEXT: Cellular Reprogramming randomized randomized -
Transconjunctival lower blepharoplasty with orbital fat repositioning versus fat grafting for tear trough deformity: A prospective, comparative and randomized study.
TL;DRA prospective, randomized controlled trial to systematically compare the modified TCLB technique with traditional TCLB in two groups demonstrates the favorable therapeutic effects of the modified TCLB technique.
FULLTEXT: Cellular Reprogramming randomized randomized -
Evaluating Change in Quality of Life as Long-Term Outcome Measure Post Septorhinoplasty: A Systematic Review.
TL;DREvidence on long-term QoL changes following septo-/rhinoplasty is synthesized, predictors of improved outcomes are identified, and recommendations to optimize patient satisfaction are offered.
FULLTEXT: Cellular Reprogramming randomized randomized -
Outcomes of Open Versus Closed Rhinoplasty, a Systematic Review and Meta-analysis.
TL;DROpen and closed rhinoplasty techniques show similar efficacy and should be tailored to patient needs and surgeon expertise, and continued innovation and standardized research are essential to optimize outcomes.
FULLTEXT: Cellular Reprogramming randomized randomized -
Deep Learning Empowered Parallelized Metasurface Computed Tomography Snapshot Spectral Imaging.
TL;DRAn ultracompact strategy of parallelized metasurface computed tomography empowered by generative deep learning is proposed, which can effectively reduce the optics volume in snapshot spectral imaging from cm3 scale to su…
FULLTEXT: Cellular Reprogramming randomized randomized