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Recent research has highlighted the critical role of copper metabolism and a novel form of copper-dependent cell death, termed cuproptosis, in the progression and treatment of these cancers. Copper, an essential trace element, plays a cruci…

[PURPOSE] To evaluate long-term reoperation risk after bilateral lateral rectus (BLR) recession for intermittent exotropia (IXT) in a paediatric cohort, and to identify the perioperative factors associated with recurrence and reoperation. …

To investigate the cost-effectiveness of pembrolizumab in combination with trastuzumab and chemotherapy as a first-line treatment for HER2-positive gastric or gastro-esophageal junction adenocarcinoma from the perspective of the U.S. and Ch…

The output signal of the sensor is closely correlated with its detection sensitivity, while the selection of luminescent materials and the presence of interfering substances in the detection medium can both affect the output signal. In this…

Interleukin-2 (IL-2) displays high affinity for IL-2Rα at physiological pH, but low affinity in the acidic tumor microenvironment (TME), which brings side effects and reduces anti-tumor activity. This pH-dependent affinity modulation is att…

Head and neck cancer (HNC) presents significant clinical challenges due to its complex tumor biology, heterogeneous microenvironment, and limited therapeutic outcomes. Hydrogels, an innovative biopolymeric material, have gained considerable…

[AIMS] This review aims to systematically examine the regulatory mechanisms of Lymphocyte Activation Gene 3 (LAG3) in modulating T regulatory cell (Treg) function and its context-dependent implications in major inflammatory and autoimmune d…

The Krüppel-like family (KLF) are important transcriptional regulators that have important, context-specific roles in gastrointestinal (GI) malignancies. Their roles are very heterogeneous; each of the KLF members may play tumor-suppressive…

[BACKGROUND] Breast cancer remains the most common type of cancer affecting women. The estrogen receptor status of a tumor defines the therapeutic approach, which often includes endocrine treatment. Therefore, identifying potential endocrin…

TL;DRAlthough challenges remain, ZnT1 is rapidly evolving from a basic transport protein to a promising precision medicine target, and Continued efforts in structural biology, single-cell metallomics and targeted delivery sys…

Diffuse large B cell lymphoma (DLBCL) is one of the most aggressive hematological diseases. Angiogenesis is one of the important aspects of DLBCL, providing the basics for tumor growth and metastasis. In this review, we discussed the Vascul…

TL;DRAge, urinary frequency, AGR, urinary urobilinogen, and CK20 were strongly associated with OS, and these prognostic factors may serve as a valuable tool in guiding patients with MIBC accompanied by iPCa.

TL;DRThe proposed EGA-PPO framework effectively connects traditional decoction principles with modern AI-based drug design and provides a scalable and interpretable strategy for de novo molecular discovery.

The application of artificial intelligence in computational pathology depends on both robust algorithms and high-quality, clinically reliable data. Progress in this field has been limited by the scarcity of large, diverse, and well-validate…

TL;DRA novel co‐produced intervention tool aimed at facilitating discussions that lung cancer nurses have with lung cancer patients about clinical trial opportunities; and promote trial recruitment to increase recruitment to …

Tumor angiogenesis plays a crucial role in tumor metastasis as it provides uninterrupted supply of oxygen and nutrients to the rapidly growing tumor cells. The Food and Drug Administration (FDA) recommends that anti-angiogenesis should be u…

TL;DRThis review systematically summarizes the molecular pathogenesis of RET fusion-positive PTC, encompassing the structure and function of the RET proto-oncogene and its encoded protein, the molecular characteristics of fus…

[BACKGROUND] Axillary surgery for breast cancer is frequently associated with upper-limb morbidity, impacting quality of life. Structured exercise improves outcomes, but access to physiotherapy is inconsistent. Wearable devices offer object…

TL;DRCompared with the CO2 laser, the electrotome and steel knife showed less damage and better healing, while the plasma radiofrequency ablation showed the most obvious thermal burns to laryngeal and vocal tissues during sur…

TL;DRAn emerging microsurgery center will achieve stability after 200 free flap procedures, while prioritizing RFFF and LD flaps as basic or lifeboat options is crucial, by analyzing free flap viability rate over 10 years.