Exploring the Diagnostic Utility of 68 Ga-FAPI-46 PET/CT in Diverse Pulmonary Pathologies : A Comparative Analysis With 18 F-FDG PET/CT.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: suspected lung lesions underwent both 18 F-FDG and 68 Ga-FAPI PET/CT scans
I · Intervention 중재 / 시술
both 18 F-FDG and 68 Ga-FAPI PET/CT scans
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
추출되지 않음
[PURPOSE] Lung cancer is the leading cause of cancer-related deaths globally.
- p-value P =0.002
- p-value P =0.001
- Sensitivity 73.1%
- Specificity 78.6%
APA
Purohit P, Aggarwal P, et al. (2026). Exploring the Diagnostic Utility of 68 Ga-FAPI-46 PET/CT in Diverse Pulmonary Pathologies : A Comparative Analysis With 18 F-FDG PET/CT.. Clinical nuclear medicine, 51(2), e92-e99. https://doi.org/10.1097/RLU.0000000000006186
MLA
Purohit P, et al.. "Exploring the Diagnostic Utility of 68 Ga-FAPI-46 PET/CT in Diverse Pulmonary Pathologies : A Comparative Analysis With 18 F-FDG PET/CT.." Clinical nuclear medicine, vol. 51, no. 2, 2026, pp. e92-e99.
PMID
41359910 ↗
Abstract 한글 요약
[PURPOSE] Lung cancer is the leading cause of cancer-related deaths globally. Computed tomography (CT) and 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) often struggle to distinguish between benign and malignant lesions, prompting interest in newer tracers, such as 68 Ga-Fibroblast activation protein inhibitor (FAPI). This prospective study is a comparative analysis for lung lesion characterization using 68 Ga-FAPI-46 PET and 18 F-FDG PET.
[PATIENTS AND METHODS] Patients with suspected lung lesions underwent both 18 F-FDG and 68 Ga-FAPI PET/CT scans. Based on histopathology, they were classified into benign or malignant groups. PET-based semi-quantitative analysis was performed, and receiver operating characteristic (ROC) analysis was conducted to determine the optimal SUVmax cut-off for differentiating benign from malignant lesions.
[RESULTS] Sixty-six patients were prospectively included in the study (mean age: 57.5±1.7 y) with 14 benign and 52 malignant lesions on histopathology. SUVmax of benign (9.8 vs. 8.8, P =0.6) and malignant lesions (14.7 vs. 13.5, P =0.8) were comparable on 68 Ga-FAPI and 18 F-FDG PET, respectively. However, a statistically significant difference was noted between the median SUVmax of benign and malignant lesions on 68 Ga-FAPI (9.8 vs. 14.7, P =0.002) and 18 F-FDG PET (8.8 vs. 13.5, P =0.001). ROC analysis revealed a SUVmax cut-off of 12.2 (sensitivity-73.1%, specificity-78.6%, AUC-0.77) and 9.5 (sensitivity-82.7%, specificity-64.3%, AUC-0.78) to differentiate benign from malignant lesions on 68 Ga-FAPI and 18 F-FDG PET, respectively.
[CONCLUSIONS] 68 Ga-FAPI-46 PET/CT exhibits potential as an alternative to FDG PET for lung lesion characterization, but requires cautious interpretation due to possible false-positive findings from benign lesions and false-negative findings from low-grade tumors, necessitating histopathologic confirmation.
[PATIENTS AND METHODS] Patients with suspected lung lesions underwent both 18 F-FDG and 68 Ga-FAPI PET/CT scans. Based on histopathology, they were classified into benign or malignant groups. PET-based semi-quantitative analysis was performed, and receiver operating characteristic (ROC) analysis was conducted to determine the optimal SUVmax cut-off for differentiating benign from malignant lesions.
[RESULTS] Sixty-six patients were prospectively included in the study (mean age: 57.5±1.7 y) with 14 benign and 52 malignant lesions on histopathology. SUVmax of benign (9.8 vs. 8.8, P =0.6) and malignant lesions (14.7 vs. 13.5, P =0.8) were comparable on 68 Ga-FAPI and 18 F-FDG PET, respectively. However, a statistically significant difference was noted between the median SUVmax of benign and malignant lesions on 68 Ga-FAPI (9.8 vs. 14.7, P =0.002) and 18 F-FDG PET (8.8 vs. 13.5, P =0.001). ROC analysis revealed a SUVmax cut-off of 12.2 (sensitivity-73.1%, specificity-78.6%, AUC-0.77) and 9.5 (sensitivity-82.7%, specificity-64.3%, AUC-0.78) to differentiate benign from malignant lesions on 68 Ga-FAPI and 18 F-FDG PET, respectively.
[CONCLUSIONS] 68 Ga-FAPI-46 PET/CT exhibits potential as an alternative to FDG PET for lung lesion characterization, but requires cautious interpretation due to possible false-positive findings from benign lesions and false-negative findings from low-grade tumors, necessitating histopathologic confirmation.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Positron Emission Tomography Computed Tomography
- Fluorodeoxyglucose F18
- Middle Aged
- Male
- Female
- Aged
- Lung Neoplasms
- Gallium Radioisotopes
- Membrane Proteins
- ROC Curve
- Adult
- Prospective Studies
- Quinolines
- carcinoma
- lung neoplasms
- non–small cell lung
- positron emission tomography computed tomography
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