The Synthesis, Metal Exchange, and Hyaluronate Functionalization of a Cationic Gallium-Based Thiosemicarbazone Anticancer Drug.
We herein demonstrate that the thiosemicarbazone (TSC) ligand N'-(di(pyridin-2-yl)methylene)-4-(thiazol-2-yl)piperazine-1-carbothiohydrazide (H) can coordinate with Ga to give cationic complex featur
APA
Ning Y, Dong ML, et al. (2026). The Synthesis, Metal Exchange, and Hyaluronate Functionalization of a Cationic Gallium-Based Thiosemicarbazone Anticancer Drug.. Molecules (Basel, Switzerland), 31(3). https://doi.org/10.3390/molecules31030577
MLA
Ning Y, et al.. "The Synthesis, Metal Exchange, and Hyaluronate Functionalization of a Cationic Gallium-Based Thiosemicarbazone Anticancer Drug.." Molecules (Basel, Switzerland), vol. 31, no. 3, 2026.
PMID
41683553
Abstract
We herein demonstrate that the thiosemicarbazone (TSC) ligand N'-(di(pyridin-2-yl)methylene)-4-(thiazol-2-yl)piperazine-1-carbothiohydrazide (H) can coordinate with Ga to give cationic complex featuring an octahedral Ga(III) center. undergoes metathesis with both Fe and Fe, resulting in the formation of respective Fe- and Fe complexes. is also susceptible to anion exchange with sodium hyaluronate (NaA) to produce the nanoformulation with boosted aqueous solubility and cell targeting. demonstrated remarkable in vitro cytotoxicity against NCI-H82 and A549 (lung cancer), as well as KYSE-510 and Te-1 (esophageal cancer) cell lines, featuring half maximal inhibitory concentration (IC) values in the range 0.102-2.616 μmol L. This work highlights the potential of using non-toxic and biocompatible Ga as the central ion to prepare TSC-based nanomedicines for combating cancer.
MeSH Terms
Humans; Antineoplastic Agents; Hyaluronic Acid; Thiosemicarbazones; Gallium; Cell Line, Tumor; Cations; Coordination Complexes; Molecular Structure; A549 Cells
같은 제1저자의 인용 많은 논문 (5)
- Targeting neutrophil-driven immunosuppression: A strategy to overcome immune checkpoint inhibitor resistance.
- Detection of cytogenetic abnormalities using optical genome mapping in T-cell lymphoid leukemia with low mitotic index.
- β-Glucan nanotubes loaded with iron diselenide for enhanced photothermal and photodynamic therapy in hepatocellular carcinoma.
- Pancreatic cancer in China: the analysis of cancer mortality and burden in China, 2008-2021.
- Simvastatin induces ferroptosis and activates anti-tumor immunity to sensitize anti-PD-1 immunotherapy in microsatellite stable gastric cancer.