Pancreatic cancer in China: the analysis of cancer mortality and burden in China, 2008-2021.
[OBJECTIVE] To understand the baseline characteristics and changing trends of pancreatic cancer mortality and disease burden, we statistically analyze the mortality data among Chinese residents from 2
APA
Ning Y, Mu J, et al. (2025). Pancreatic cancer in China: the analysis of cancer mortality and burden in China, 2008-2021.. BMC cancer, 25(1), 1852. https://doi.org/10.1186/s12885-025-15223-4
MLA
Ning Y, et al.. "Pancreatic cancer in China: the analysis of cancer mortality and burden in China, 2008-2021.." BMC cancer, vol. 25, no. 1, 2025, pp. 1852.
PMID
41340043
Abstract
[OBJECTIVE] To understand the baseline characteristics and changing trends of pancreatic cancer mortality and disease burden, we statistically analyze the mortality data among Chinese residents from 2008 to 2021.
[METHODS] Pancreatic cancer mortality data were selected from . We calculated Crude Mortality Rate (CMR), age-standardized mortality rate (ASMR), potential years of life lost (PYLL), and PYLL rate (PYLLR) stratified by sex, age, urban/rural residence, and region (eastern/central/western China). The average annual percentage change (AAPC) was used to quantify trends in ASMR and PYLLR. Chi-square tests (R4.4.3) assessed mortality differences across subgroups, while an age-period-cohort (APC) model analyzed the effects of age, period, and birth cohort on mortality trends.
[RESULTS] The ASMR of pancreatic cancer in China increased from 3.67/100,000 in 2008 to 4.45/100,000 in 2021 (AAPC = 1.09%), while PYLLR rose from 0.23% to 0.35% (AAPC = 3.13%). Subgroup disparities: Both ASMR and PYLLR were higher in males than females, urban than rural areas, and eastern > central > western regions. Burden acceleration: The fastest increases occurred in males (vs. females), rural (vs. urban), and western > central > eastern regions.
[CONCLUSION] Pancreatic cancer mortality and disease burden in China show a sustained upward trend, disproportionately affecting older adults, males, urban residents, and eastern populations. Rapid escalation in males, rural areas, and western regions underscores the need for targeted interventions.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12885-025-15223-4.
[METHODS] Pancreatic cancer mortality data were selected from . We calculated Crude Mortality Rate (CMR), age-standardized mortality rate (ASMR), potential years of life lost (PYLL), and PYLL rate (PYLLR) stratified by sex, age, urban/rural residence, and region (eastern/central/western China). The average annual percentage change (AAPC) was used to quantify trends in ASMR and PYLLR. Chi-square tests (R4.4.3) assessed mortality differences across subgroups, while an age-period-cohort (APC) model analyzed the effects of age, period, and birth cohort on mortality trends.
[RESULTS] The ASMR of pancreatic cancer in China increased from 3.67/100,000 in 2008 to 4.45/100,000 in 2021 (AAPC = 1.09%), while PYLLR rose from 0.23% to 0.35% (AAPC = 3.13%). Subgroup disparities: Both ASMR and PYLLR were higher in males than females, urban than rural areas, and eastern > central > western regions. Burden acceleration: The fastest increases occurred in males (vs. females), rural (vs. urban), and western > central > eastern regions.
[CONCLUSION] Pancreatic cancer mortality and disease burden in China show a sustained upward trend, disproportionately affecting older adults, males, urban residents, and eastern populations. Rapid escalation in males, rural areas, and western regions underscores the need for targeted interventions.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12885-025-15223-4.
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