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IL-6 drives chemoimmunotherapy resistance in NSCLC by reprogramming myeloid cells and impairing cytotoxic lymphocyte function.

1/5 보강
Cancer letters 📖 저널 OA 17.5% 2023: 1/3 OA 2024: 6/34 OA 2025: 14/119 OA 2026: 44/210 OA 2023~2026 2026 Vol.641() p. 218259
Retraction 확인
출처
PubMed DOI

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문
P · Population 대상 환자/모집단
환자: high baseline plasma IL-6 levels (>7
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Mechanistically, IL-6 drives formation of an immunosuppressive TIME by promoting protumour macrophage polarisation. This, in turn, suppress cytotoxic T cell infiltration, promoting Treg expansion, and impairing NK cell function, indicating that the targeting of IL-6 represents a promising strategy to overcome resistance to chemoimmunotherapy.

Yang Y, Liu C, Yang L, Zheng S, Xu H, Zhang S

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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