Chronic obstructive pulmonary disease as a double-edged sword-reshaping NSCLC immunotherapy paradigms.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: COPD exhibit superior anti-PD-1 responses through a distinctive immunological mechanism
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
COPD-driven epithelial remodeling expands CXCL14+ basal-like tumor cells, which orchestrate CXCL9+ macrophage recruitment via CXCL14-CXCR4 signaling, amplifying cytotoxic T cell infiltration. This COPD-associated tumor-macrophage axis predicts pathological response and represents both a promising biomarker and potential therapeutic target for refining immunotherapy strategies.
OpenAlex 토픽 ·
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Chronic Obstructive Pulmonary Disease (COPD) Research
Cancer Immunotherapy and Biomarkers
Chen et al.
APA
Haowei Wang, Tao Jiang (2026). Chronic obstructive pulmonary disease as a double-edged sword-reshaping NSCLC immunotherapy paradigms.. Med (New York, N.Y.), 7(4), 101032. https://doi.org/10.1016/j.medj.2026.101032
MLA
Haowei Wang, et al.. "Chronic obstructive pulmonary disease as a double-edged sword-reshaping NSCLC immunotherapy paradigms.." Med (New York, N.Y.), vol. 7, no. 4, 2026, pp. 101032.
PMID
41966713 ↗
Abstract 한글 요약
Chen et al. demonstrate that NSCLC patients with COPD exhibit superior anti-PD-1 responses through a distinctive immunological mechanism. COPD-driven epithelial remodeling expands CXCL14+ basal-like tumor cells, which orchestrate CXCL9+ macrophage recruitment via CXCL14-CXCR4 signaling, amplifying cytotoxic T cell infiltration. This COPD-associated tumor-macrophage axis predicts pathological response and represents both a promising biomarker and potential therapeutic target for refining immunotherapy strategies.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- Application and progress of nomograms in gastric cancer.
- Safety and Efficacy of Selective Neurectomy of the Gastrocnemius Muscle for Calf Reduction in 300 Cases.
- Application of machine learning algorithms and establishment of a web calculator in predicting distant metastasis of T2-T4 gastric cancer.
- Preoperative frailty prevalence and risk factors in oral cancer patients: a meta-analysis.
- Lipidomics and single-cell transcriptomics uncover aberrant lipid metabolism in metaplasia lesions during gastric carcinogenesis.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.