Piperacillin/Tazobactam-Induced Granulomatous Interstitial Nephritis in a Patient with Squamous Cell Lung Cancer Successfully Managed with Chemoradiotherapy.
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OpenAlex 토픽 ·
Nephrotoxicity and Medicinal Plants
Sarcoidosis and Beryllium Toxicity Research
Drug-Induced Adverse Reactions
Drug-induced acute interstitial nephritis (DI-AIN) is a common cause of acute kidney injury (AKI), particularly in patients receiving multiple medications.
APA
Takuya Sugiura, Kazuo Tsuchiya, et al. (2026). Piperacillin/Tazobactam-Induced Granulomatous Interstitial Nephritis in a Patient with Squamous Cell Lung Cancer Successfully Managed with Chemoradiotherapy.. Internal medicine (Tokyo, Japan). https://doi.org/10.2169/internalmedicine.7024-25
MLA
Takuya Sugiura, et al.. "Piperacillin/Tazobactam-Induced Granulomatous Interstitial Nephritis in a Patient with Squamous Cell Lung Cancer Successfully Managed with Chemoradiotherapy.." Internal medicine (Tokyo, Japan), 2026.
PMID
42021034 ↗
Abstract 한글 요약
Drug-induced acute interstitial nephritis (DI-AIN) is a common cause of acute kidney injury (AKI), particularly in patients receiving multiple medications. We report a case of AKI in a 47-year-old man with lung squamous cell carcinoma who was treated with carboplatin, paclitaxel, and tazobactam/piperacillin (TAZ/PIPC). A renal biopsy revealed acute tubulointerstitial nephritis with eosinophilic infiltration and non-caseating epithelioid granulomas. The drug lymphocyte stimulation test was positive for TAZ/PIPC, thus supporting a diagnosis of drug-associated DI-AIN. The discontinuation of TAZ/PIPC and corticosteroid therapy led to a recovery of the renal function, thereby allowing for the safe resumption of chemotherapy.
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