Limbic encephalitis associated with anti-Hu antibody induced by atezolizumab treatment for small cell lung cancer: A case report.
OpenAlex 토픽 ·
Autoimmune Neurological Disorders and Treatments
Cancer Immunotherapy and Biomarkers
Cytomegalovirus and herpesvirus research
With the emergence and frequent use of immune checkpoint inhibitors (ICIs), reports of immunotherapy-induced limbic encephalitis have begun to appear.
APA
Zhaohui Li, Hanping Wang (2026). Limbic encephalitis associated with anti-Hu antibody induced by atezolizumab treatment for small cell lung cancer: A case report.. Oncology letters, 31(5), 177. https://doi.org/10.3892/ol.2026.15532
MLA
Zhaohui Li, et al.. "Limbic encephalitis associated with anti-Hu antibody induced by atezolizumab treatment for small cell lung cancer: A case report.." Oncology letters, vol. 31, no. 5, 2026, pp. 177.
PMID
41918809
Abstract
With the emergence and frequent use of immune checkpoint inhibitors (ICIs), reports of immunotherapy-induced limbic encephalitis have begun to appear. The present study describes the case of a patient with small cell lung cancer who developed Hu-associated limbic encephalitis while being treated with atezolizumab. After treatment with high-dose steroids and intravenous immunoglobulin, the neurological symptoms of the patient (including confusion, short-term memory loss, disorientation, and impaired calculation ability) remained stable for 3 months, after which the patient was lost to follow-up. ICIs may accelerate autoimmune reactions that target paraneoplastic origin autoantigens. Clinicians should be alert to the risk of ICI-induced paraneoplastic neurological syndromes in patients with tumors, such as small cell lung cancer, that are traditionally associated with paraneoplastic neurological syndromes.
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