Ferroptosis in reproductive system disorders: Pathological roles and therapeutic potential.

Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival status of germ cells and the structure and function of reproductive tissues, including polycystic ovary syndrome, endometriosis and spermatogenic disorder. Researchers are actively exploring the therapeutic potential of ferroptosis in reproductive system diseases. Ferroptosis can serve as a potential therapeutic target for clinical treatment, which can be combined with existing therapies, allowing for personalized treatment plans based on patients' conditions. The study of ferroptosis not only provides a new perspective on the pathogenesis of reproductive system diseases, but also offers a theoretical basis for developing novel therapeutic drugs. With a deeper understanding of the ferroptosis mechanism, treatment strategies based on it are expected to become an important means of treating reproductive system diseases in the future. This will bring new hope for improving patients' reproductive health and enhancing their quality of life.