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A phase II study of docetaxel and pembrolizumab plus Interleukin-12 gene therapy in non-metastatic, anthracycline-refractory triple negative breast cancer (INTEGRAL).

1/5 보강

Clinical cancer research : an official journal of the American Association for Cancer Research 📖 저널 OA 54.5% 2022~2026 2026

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문

P · Population 대상 환자/모집단

4 patients received 3 x 1011 viral particles.

I · Intervention 중재 / 시술

neoadjuvant docetaxel (100 mg/m2 IV) and pembrolizumab (200 mg IV) every three weeks for four cycles

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

These results underscore the need for cautious dose optimization and patient selection when integrating immuno-potentiating cytokines into neoadjuvant regimens. Translational insights from this study inform safer design of future IL-12-based strategies in immune-refractory TNBC.

Niravath P, Uzair I, Sun K, Mai H, Guan J, Li M

📖 무료 전문 🟢 PMC 전문 PMC13012616

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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