Features and functional mechanisms of super-enhancers in cardiovascular disorders, cancer, autoimmune diseases and neurodegenerative disorders.
1/5 보강
Super-enhancers (SEs) constitute specialized genomic regulatory hubs defined by high density agglomeration of transcriptional machinery, transcription factors (TFs), and chromatin-modifying complexes.
APA
Li ZR, Wang YY, et al. (2026). Features and functional mechanisms of super-enhancers in cardiovascular disorders, cancer, autoimmune diseases and neurodegenerative disorders.. Cellular signalling, 138, 112252. https://doi.org/10.1016/j.cellsig.2025.112252
MLA
Li ZR, et al.. "Features and functional mechanisms of super-enhancers in cardiovascular disorders, cancer, autoimmune diseases and neurodegenerative disorders.." Cellular signalling, vol. 138, 2026, pp. 112252.
PMID
41253192 ↗
Abstract 한글 요약
Super-enhancers (SEs) constitute specialized genomic regulatory hubs defined by high density agglomeration of transcriptional machinery, transcription factors (TFs), and chromatin-modifying complexes. These higher order chromatin architectures serve as pivotal epigenetic orchestrators that sustain cell identity by synchronizing the expression of lineage-specifying genes, while also playing instrumental roles in the pathogenesis of diverse diseases. This comprehensive review systematically delineates the architectural hierarchy and dynamic assembly mechanisms of SEs, with a focused emphasis on liquid-liquid phase separation (LLPS) driven biomolecular condensate formation and concomitant three-dimensional (3D) chromatin reorganization. We critically examine the implications of SEs mediated transcriptional dysregulation across a range of pathological contexts, including cardiovascular disorders (CVDs), cancer, autoimmune diseases, and neurodegenerative conditions. From a therapeutic perspective, we evaluate innovative targeting strategies directed against SEs components, encompassing synthetic biology constructs, CRISPR-based genomic interventions, epigenetic modulators, and combinatory immunotherapies. Furthermore, we highlight current research hotspots and emerging future directions in the field.
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