Role of the C-reactive protein-albumin ratio in predicting survival after breast cancer: A systematic review and meta-analysis.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
427 patients were included.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
PROSPERO database (CRD420251181780).
[OBJECTIVE] This review aimed to evaluate the association between C-reactive protein-albumin ratio (CAR) and survival outcomes in patients with breast cancer.
- 95% CI 1.64-4.31
- HR 2.66
APA
Wang H, Yao L (2026). Role of the C-reactive protein-albumin ratio in predicting survival after breast cancer: A systematic review and meta-analysis.. Pakistan journal of medical sciences, 42(3), 773-783. https://doi.org/10.12669/pjms.42.3.14536
MLA
Wang H, et al.. "Role of the C-reactive protein-albumin ratio in predicting survival after breast cancer: A systematic review and meta-analysis.." Pakistan journal of medical sciences, vol. 42, no. 3, 2026, pp. 773-783.
PMID
41994405
Abstract
[OBJECTIVE] This review aimed to evaluate the association between C-reactive protein-albumin ratio (CAR) and survival outcomes in patients with breast cancer.
[METHODOLOGY] Databases of PubMed, Embase, Scopus, and Web of Science were searched up to 3 November 2025. Included studies involved adult patients with histologically confirmed breast cancer that reported hazard ratios (HRs) and 95% confidence intervals (CIs) for either overall survival (OS) or disease-free survival (DFS).
[RESULTS] Six studies involving 2,427 patients were included. The pooled analysis demonstrated that elevated CAR was significantly linked with worse OS (HR = 2.66, 95% CI 1.64-4.31) and poorer DFS (HR = 2.39, 95% CI 1.50-3.82). Subgroup analyses revealed consistent associations across study design, cancer subtype, stage, country, and follow-up duration. Meta-regression showed that CAR cut-off value did not significantly influence the effect size for either OS or DFS. Sensitivity analyses indicated stable results.
[CONCLUSIONS] An elevated CAR may be associated with poorer OS and DFS in breast cancer. Given the scarce evidence, further research is needed to provide robust results. PROSPERO database (CRD420251181780).
[METHODOLOGY] Databases of PubMed, Embase, Scopus, and Web of Science were searched up to 3 November 2025. Included studies involved adult patients with histologically confirmed breast cancer that reported hazard ratios (HRs) and 95% confidence intervals (CIs) for either overall survival (OS) or disease-free survival (DFS).
[RESULTS] Six studies involving 2,427 patients were included. The pooled analysis demonstrated that elevated CAR was significantly linked with worse OS (HR = 2.66, 95% CI 1.64-4.31) and poorer DFS (HR = 2.39, 95% CI 1.50-3.82). Subgroup analyses revealed consistent associations across study design, cancer subtype, stage, country, and follow-up duration. Meta-regression showed that CAR cut-off value did not significantly influence the effect size for either OS or DFS. Sensitivity analyses indicated stable results.
[CONCLUSIONS] An elevated CAR may be associated with poorer OS and DFS in breast cancer. Given the scarce evidence, further research is needed to provide robust results. PROSPERO database (CRD420251181780).
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