New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment.

Hydrogen synergistic therapy, an emerging and promising strategy in tumor treatment, has been bolstered by nanotechnology to establish a stable and multifunctional foundation for its implementation. Hydrogen-synergistic diagnostic and therapeutic nanoplatforms (HSDT-NPs), a novel type of tool for tumor treatment, integrate hydrogen therapy with various tumor diagnostic and therapeutic strategies, significantly enhancing the efficiency and specificity of tumor treatment, which is crucial for achieving precision therapy at the tumor site. The construction of HSDT-NPs relies on the design of hydrogen nanomaterials and the selection and assembly of synergistic units. Through HSDT-NPs, the synergistic effects between hydrogen therapy and other strategies are markedly enhanced, not only improving the efficacy of traditional therapies on tumors but also effectively protecting normal cells. Based on different material types, this study explores the construction strategies of HSDT-NPs. Subsequently, focusing on the collaborative treatment modes, it delves into the synergistic mechanisms of HSDT-NPs. Our work aims to offer new perspectives and innovative approaches for advancing cancer treatment based on hydrogen therapy research.