Integrin-dependent neutrophil slowing reduces lung perfusion and supports metastasis in a model of breast cancer.
1/5 보강
Neutrophils are critical in establishing a tumor-cell-nurturing and immunosuppressive pulmonary "pre-metastatic" niche in breast cancer.
APA
Fercoq F, Cairns GS, et al. (2026). Integrin-dependent neutrophil slowing reduces lung perfusion and supports metastasis in a model of breast cancer.. Cell reports, 45(3), 117101. https://doi.org/10.1016/j.celrep.2026.117101
MLA
Fercoq F, et al.. "Integrin-dependent neutrophil slowing reduces lung perfusion and supports metastasis in a model of breast cancer.." Cell reports, vol. 45, no. 3, 2026, pp. 117101.
PMID
41838721 ↗
Abstract 한글 요약
Neutrophils are critical in establishing a tumor-cell-nurturing and immunosuppressive pulmonary "pre-metastatic" niche in breast cancer. The localization and behavior of these neutrophils is, however, not well described. Using multiplexed imaging to investigate the pre-metastatic lung in a spontaneously metastatic mammary cancer model, we uncover that neutrophils with impaired intravascular motility congest the capillaries of pre-metastatic lungs. Slowed neutrophil transit is reversed by activating β integrin with an antibody and can be recapitulated by treating non-tumor-bearing mice with G-CSF. Neutrophil congestion causes a reduction of intravenously injected microbeads in the lung, suggestive of lower perfusion. In a model where tumor cells are injected intravenously into mammary-cancer-bearing Rag1-deficient mice, we observe lower lung experimental metastasis burdens after activating β integrins. Overall, our study proposes that integrin-mediated neutrophil congestion of the alveolar capillaries contributes to the pulmonary pre-metastatic niche.
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