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Cancer-Associated Thrombosis, With a Focus on Ischemic Heart Disease.

Circulation journal : official journal of the Japanese Circulation Society 2026 Vol.90(4) p. 371-375

Hara T, Sata M

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Cancer is widely recognized as one of the major risk factors for thrombosis, and cancer-associated thrombosis (CAT) is a concept that also encompasses arterial and venous thromboembolism.

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APA Hara T, Sata M (2026). Cancer-Associated Thrombosis, With a Focus on Ischemic Heart Disease.. Circulation journal : official journal of the Japanese Circulation Society, 90(4), 371-375. https://doi.org/10.1253/circj.CJ-25-0627
MLA Hara T, et al.. "Cancer-Associated Thrombosis, With a Focus on Ischemic Heart Disease.." Circulation journal : official journal of the Japanese Circulation Society, vol. 90, no. 4, 2026, pp. 371-375.
PMID 40887291

Abstract

Cancer is widely recognized as one of the major risk factors for thrombosis, and cancer-associated thrombosis (CAT) is a concept that also encompasses arterial and venous thromboembolism. The risk factors for CAT of clinical concern are assumed to be a complex combination of patient-related factors, the cancer itself, factors related to anticancer therapy, tissue factors expressed on cancer cell membranes, and cytokines released by cancer cells to increase inflammation and coagulation at remote sites. In addition, some anticancer agents are known to damage vascular endothelial cells and cause thrombus formation; early diagnosis and treatment of CAT is recommended because CAT is a significant risk factor for poor prognosis in cancer patients.

MeSH Terms

Humans; Thrombosis; Neoplasms; Myocardial Ischemia; Risk Factors; Antineoplastic Agents

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