The multifaceted roles of G protein-coupled receptor C3aR1 in disease: From immunomodulation to cancer progression.
2/5 보강
TL;DR
This review provides a comprehensive and in-depth overview of the structure and function of C3aR1, its mechanisms of action in various diseases, and its potential as a therapeutic target.
OpenAlex 토픽 ·
Complement system in diseases
Monoclonal and Polyclonal Antibodies Research
Vagus Nerve Stimulation Research
This review provides a comprehensive and in-depth overview of the structure and function of C3aR1, its mechanisms of action in various diseases, and its potential as a therapeutic target.
APA
Jiayao Cui, Fangyu Shen, et al. (2026). The multifaceted roles of G protein-coupled receptor C3aR1 in disease: From immunomodulation to cancer progression.. Pathology, research and practice, 280, 156386. https://doi.org/10.1016/j.prp.2026.156386
MLA
Jiayao Cui, et al.. "The multifaceted roles of G protein-coupled receptor C3aR1 in disease: From immunomodulation to cancer progression.." Pathology, research and practice, vol. 280, 2026, pp. 156386.
PMID
41643632 ↗
Abstract 한글 요약
C3aR1 (complement component 3a receptor 1), a key member of the complement system, belongs to the G protein-coupled receptor (GPCR) family. It plays an indispensable role in physiological processes such as immunomodulation, inflammatory response, and cellular signaling through specific binding to its ligand C3a. In recent years, numerous studies have demonstrated the significant role of C3aR1 in the pathogenesis of various diseases, including inflammatory diseases, cardiovascular diseases, and tumors. Particularly within the tumor microenvironment (TME), C3aR1 can promote tumor progression by regulating key processes such as immune evasion, angiogenesis, and cell invasion. This review provides a comprehensive and in-depth overview of the structure and function of C3aR1, its mechanisms of action in various diseases, and its potential as a therapeutic target.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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