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Covalent versus Dimeric Optimization of Nectin-4-Targeted Peptide Radiotracers: A Head-to-Head Comparison in Triple-Negative Breast Cancer Mice Models.

2/5 보강

Molecular pharmaceutics 📖 저널 OA 23.1% 2023~2026 2026 Vol.23(4) p. 2693-2703 Wnt/β-catenin signaling in developme

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문

P · Population 대상 환자/모집단

추출되지 않음

I · Intervention 중재 / 시술

Covalent

C · Comparison 대조 / 비교

Dimeric Optimization of Nectin

O · Outcome 결과 / 결론

Taken together, these findings demonstrate that dimerization enhances molecular recognition through multivalency, while sulfonyl fluoride modification prolongs tumor residence and improves imaging contrast. The complementary advantages of these two strategies establish a rational framework for the design of next-generation Nectin-4-targeted radiotracers.

OpenAlex 토픽 · Wnt/β-catenin signaling in development and cancer Proteoglycans and glycosaminoglycans research Mast cells and histamine

Pei Y, Zhou X, Gao F, Sun M, Qiu S, Qin X

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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