Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.

Erik Storrs; Chia-Kuei Mo; Wen-hung Chou; Gaurav Bhatt; Siqi Chen; Xiyi Wei; Andrew Houston; Alla Karpova; Reyka G. Jayasinghe; Preet Lal; Peter Bayguinov; John M. Herndon; Xiang Li; Faria Anjum Simin; Xiangwei Fang; Michael C. Wendl; Xinhao Liu; Hongyu Zheng; Sherri R. Davies; J Wang; Andrew Shinkle; Robert S. Fulton; Jennifer Ponce; Michael Heinz; Richard Head; De Chen; Yuting Zhao; David Fenyö; Y S Li; Cynthia X. Ma; Rebecca Aft; Melissa A. Reimers; Albert H. Kim; Sidharth V. Puram; James A. J. Fitzpatrick; Kooresh I. Shoghi; R. Sherburne Figenshau; Foluso O. Ademuyiwa; Tao Ju; Graham A. Colditz; Bettina F. Drake; Gary J. Patti; S. Oh; Eric H. Kim; William E. Gillanders; John A. Olson; Milan G. Chheda; Cody Weimholt; Deborah J. Veis; Benjamin J. Raphael; Ryan C. Fields; Russell K. Pachynski; Feng Chen; Li Ding

doi:10.1158/2159-8290.CD-26-0012

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Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.

2/5 보강

Cancer discovery 2026 OA GDF15 and Related Biomarkers

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

51 cases revealed gene-expression features and novel structural insights defining the shift from precancer to invasive disease.

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

In prostate cancer, GDF15, ALDH1A3, ANPEP, and FASN were upregulated along invasive progression, and their knockdown in PC-3 cells suppressed proliferation and migration. Enrichment of tumor-associated macrophages (SPP1⁺, MS4A6A⁺) along non-TNBC breast cancer transitions highlights immune involvement as a potential driver of invasiveness.

OpenAlex 토픽 · GDF15 and Related Biomarkers Immune cells in cancer Single-cell and spatial transcriptomics

Storrs E, Mo CK, Chou WH, Bhatt G, Chen S, Wei X, Houston A, Karpova A, Jayasinghe RG, Lal P, Bayguinov P, Herndon JM, Li X, Anjum Simin F, Fang X, Wendl MC, Liu X, Zheng H, Davies SR, Wang JT, Shinkle A, Fulton RS, Ponce J, Heinz M, Head R, Chen D, Zhao Y, Fenyo D, Li YE, Ma CX, Aft R, Reimers MA, Kim AH, Puram SV, Fitzpatrick JAJ, Shoghi KI, Figenshau RS, Ademuyiwa FO, Ju T, Colditz GA, Drake BF, Patti GJ, Oh ST, Kim EH, Gillanders WE, Olson JA, Chheda MG, Weimholt C, Veis DJ, Raphael BJ, Fields RC, Pachynski RK, Chen F, Ding L

🔓 OA 전문 ↗ 원문 ↗ DOI ↗ BibTeX ↓ RIS ↓

📝 환자 설명용 한 줄

Breast and prostate cancers are both hormone-driven adenocarcinomas that undergo analogous invasion programs.

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BibTeX ↓ RIS ↓

APA Erik Storrs, Chia-Kuei Mo, et al. (2026). Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.. Cancer discovery. https://doi.org/10.1158/2159-8290.CD-26-0012

MLA Erik Storrs, et al.. "Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.." Cancer discovery, 2026.

PMID 41997105

DOI 10.1158/2159-8290.CD-26-0012

Abstract

Breast and prostate cancers are both hormone-driven adenocarcinomas that undergo analogous invasion programs. Using lightsheet microscopy on intact tumors, we identified transitional junctions between precancerous and invasive regions. We then developed a multimodal serial-section workflow integrating volumetric reconstruction with spatial transcriptomics. Analysis of 319 spatial assays from 51 cases revealed gene-expression features and novel structural insights defining the shift from precancer to invasive disease. In breast cancer, loss of MGP and PLAT was associated with invasive transition and promoted tumorigenesis in functional assays. In prostate cancer, GDF15, ALDH1A3, ANPEP, and FASN were upregulated along invasive progression, and their knockdown in PC-3 cells suppressed proliferation and migration. Enrichment of tumor-associated macrophages (SPP1⁺, MS4A6A⁺) along non-TNBC breast cancer transitions highlights immune involvement as a potential driver of invasiveness.