Role of disulfidptosis in cancer: Molecular mechanisms and therapeutic opportunities.

Disulfidptosis, as a novel form of programmed cell death, is different from ferroptosis and cuproptosis. Numerous studies have shown that glucose starvation is a key characteristic of disulfidptosis. Under the condition of high expression of solute carrier family 7 member 11, the content of nicotinamide adenine dinucleotide phosphate hydrogen changes, and cystine and other disulfides in cells accumulate, which leads to actin cytoskeleton collapse and subsequent cell death. This review summarizes recent discoveries of disulfidptosis, a novel form of cell death, from the scientific community in the context of cancer; it elaborates on its discovery background, molecular mechanisms, and regulatory networks, and explores the regulatory roles of its key genes and regulatory proteins. Additionally, this review discusses the prognostic value and application potential of disulfidptosis in the treatment of lung cancer, pancreatic cancer, gastric cancer, colorectal cancer, and other cancers, providing references for clinical cancer therapy.