Prognostic Significance of Different Ki-67 Cutoff Values Defined Luminal B HER2-Negative Breast Cancer.
TL;DR
It was found that luminal B (HER2-) tumors showed poor DFS regardless of Ki-67 cutoff values (14, 20 or 30%), and luminal B (HER2-) subtype(PR ≤ 20% and high Ki-67 index) tumors showed inferior OS, DMFS, and BCSS with Ki-67 cutoff value of 20.
OpenAlex 토픽 ·
Breast Cancer Treatment Studies
HER2/EGFR in Cancer Research
Cancer Treatment and Pharmacology
It was found that luminal B (HER2-) tumors showed poor DFS regardless of Ki-67 cutoff values (14, 20 or 30%), and luminal B (HER2-) subtype(PR ≤ 20% and high Ki-67 index) tumors showed inferior OS, DM
APA
Xin Ye, Xiaoyun Zhou, et al. (2026). Prognostic Significance of Different Ki-67 Cutoff Values Defined Luminal B HER2-Negative Breast Cancer.. Cancer investigation, 44(5), 463-478. https://doi.org/10.1080/07357907.2026.2617267
MLA
Xin Ye, et al.. "Prognostic Significance of Different Ki-67 Cutoff Values Defined Luminal B HER2-Negative Breast Cancer.." Cancer investigation, vol. 44, no. 5, 2026, pp. 463-478.
PMID
41627261
Abstract
Luminal B (HER2-) breast cancer is defined as ER- or PR-positive and HER2-negative meeting with PR ≤ 20%, or ER- or PR-positive and HER2-negative with high Ki-67 index, which has worse prognoses. The locally specified Ki-67 cutoff value has remained elusive in China. 4940 patients with ER- or PR-positive and HER2-negative operable breast cancer were recruited. The novel findings was that luminal B (HER2-) tumors showed poor DFS regardless of Ki-67 cutoff values (14, 20 or 30%), and luminal B (HER2-) subtype(PR ≤ 20% and high Ki-67 index) tumors showed inferior OS, DMFS, and BCSS. With Ki-67 cutoff value of 20%, it was optimized to distinguish prognostic differences.
MeSH Terms
Humans; Female; Ki-67 Antigen; Breast Neoplasms; Erb-b2 Receptor Tyrosine Kinases; Prognosis; Middle Aged; Receptors, Estrogen; Adult; Receptors, Progesterone; Biomarkers, Tumor; Aged; China
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