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Discovery of novel olaparib-β-carboline hybrids for treating BRCA-deficient triple negative breast cancer.

2/5 보강

Bioorganic & medicinal chemistry 📖 저널 OA 4% 2024~2026 2026 Vol.136() p. 118585 PARP inhibition in cancer therapy

TL;DR Mechanistically, compound 6 could increase DNA damage, induce cell cycle arrest in the G2/M phase, and promote MDA-MB-436 apoptosis, and can be a candidate compound for the treatment of BRCA-deficient TNBC.

OpenAlex 토픽 · PARP inhibition in cancer therapy Synthesis and bioactivity of alkaloids Advanced Breast Cancer Therapies

Yang X, Shen T, Wu L

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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