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Resistance mechanisms and post-trastuzumab deruxtecan (T-DXd) strategies in HER2+ and HER2-low breast cancer: From biology to clinical practice.

3/5 보강

Critical reviews in oncology/hematology 📖 저널 OA 7% 2022~2026 2026 Vol.221() p. 105179 cited 1 HER2/EGFR in Cancer Research

TL;DR Real-world data further support a "three-step strategy" involving ADC rechallenge after interim non-ADC therapies, offering a practical, mechanism-informed treatment model for precision-guided care in patients with advanced breast cancer.

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: advanced breast cancer and supports ongoing efforts to extend the therapeutic window beyond initial T-DXd benefit

I · Intervention 중재 / 시술

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C · Comparison 대조 / 비교

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O · Outcome 결과 / 결론

Real-world data further support a "three-step strategy" involving ADC rechallenge after interim non-ADC therapies, offering a practical, mechanism-informed treatment model. This review provides a framework for precision-guided care in patients with advanced breast cancer and supports ongoing efforts to extend the therapeutic window beyond initial T-DXd benefit.

OpenAlex 토픽 · HER2/EGFR in Cancer Research Advanced Breast Cancer Therapies Breast Cancer Treatment Studies

Wen X, Wang W, Song J, Chen M, Xue W, Lin D

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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