Development of palladium-based multivalent lectin-directed artificial metalloenzymes.
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TL;DR
Another example of a multivalent lectin-directed artificial metalloenzyme was developed using a palladium-embedded HaloTag-PduU-ACG lectin fusion protein (HtPA-Pd) and was shown to be biologically active against hypersialylated MDA-MB-231 breast cancer cells.
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Glycosylation and Glycoproteins Research
Supramolecular Self-Assembly in Materials
Bacteriophages and microbial interactions
Another example of a multivalent lectin-directed artificial metalloenzyme was developed using a palladium-embedded HaloTag-PduU-ACG lectin fusion protein (HtPA-Pd) and was shown to be biologically act
APA
Jing Huang, Yufei Li, et al. (2026). Development of palladium-based multivalent lectin-directed artificial metalloenzymes.. Bioorganic & medicinal chemistry, 136, 118603. https://doi.org/10.1016/j.bmc.2026.118603
MLA
Jing Huang, et al.. "Development of palladium-based multivalent lectin-directed artificial metalloenzymes.." Bioorganic & medicinal chemistry, vol. 136, 2026, pp. 118603.
PMID
41747325
Abstract 한글 요약
By instilling artificial metalloenzymes (ArMs) with cancer targeting properties, these biocatalysts can be used in prodrug therapies to chemoselectively activate prodrugs within the local tumor environment. In this study, another example of a multivalent lectin-directed artificial metalloenzyme was developed using a palladium-embedded HaloTag-PduU-ACG lectin fusion protein (HtPA-Pd). By combining the targeting ArM with a proc-masked doxorubicin prodrug, this anticancer prodrug therapy was subsequently shown in assays to be biologically active against hypersialylated MDA-MB-231 breast cancer cells.
🏷️ 키워드 / MeSH
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