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Molecular fingerprints of cell size sensing and mating type differentiation in pennate diatoms.

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The New phytologist 2025 Vol.245(4) p. 1625-1639 cited 1 OA Diatoms and Algae Research
TL;DR A method to shorten the generation time of Cylindrotheca closterium through single-cell microsurgery is developed, enabling the transcriptomic comparison of genetically identical large and undifferentiated cells with small, sexually competent cells for six different genotypes, and revealing a size-regulated gene cluster with three mating type-specific genes susceptible to sex-inducing pheromones.
🔎 핵심 키워드 미세수술 cell heart cells single-cell pennate pennate SST 전체 NER ↓
Retraction 확인
출처
PubMed DOI OpenAlex Semantic 마지막 보강 2026-04-28
OpenAlex 토픽 · Diatoms and Algae Research Protist diversity and phylogeny Aquatic Ecosystems and Phytoplankton Dynamics

Belišová D, Bilcke G, Audoor S, D'hondt S, De Veylder L, Vandepoele K, Vyverman W

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PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

관련 도메인

미세수술 Microsurgery
📈 PRS 동향 보기 📰 The New phytologist 저널 페이지 👤 Belišová D 저자 프로필 🕸️ 그래프
📝 환자 설명용 한 줄

A method to shorten the generation time of Cylindrotheca closterium through single-cell microsurgery is developed, enabling the transcriptomic comparison of genetically identical large and undifferent

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↓ .bib ↓ .ris
APA Darja Belišová, Gust Bilcke, et al. (2025). Molecular fingerprints of cell size sensing and mating type differentiation in pennate diatoms.. The New phytologist, 245(4), 1625-1639. https://doi.org/10.1111/nph.20334
MLA Darja Belišová, et al.. "Molecular fingerprints of cell size sensing and mating type differentiation in pennate diatoms.." The New phytologist, vol. 245, no. 4, 2025, pp. 1625-1639.
PMID 39648404 ↗
DOI 10.1111/nph.20334

Abstract

A unique cell size-sensing mechanism is at the heart of the life cycle of diatoms. During population growth, cell size decreases until a sexual size threshold (SST) is reached, below which cells become sexually competent. In most pennate diatoms, the two mating types undergo biochemical and behavioral differentiation below the SST, although the molecular pathways underlying their size-dependent maturation remain unknown. Here, we developed a method to shorten the generation time of Cylindrotheca closterium through single-cell microsurgery, enabling the transcriptomic comparison of genetically identical large and undifferentiated cells with small, sexually competent cells for six different genotypes. We identified 21 genes upregulated in small cells regardless of their mating type, revealing how cells undergo specific transcriptional reprogramming when passing the SST. Furthermore, we revealed a size-regulated gene cluster with three mating type-specific genes susceptible to sex-inducing pheromones. In addition, comparative transcriptomics confirmed the shared mating type specificity of Mating-type Related Minus 2 homologs in three pennate diatoms, suggesting them to be part of a conserved partner recognition mechanism. This study sheds light on how diatoms acquire sexual competence in a strictly size-dependent manner, revealing a complex machinery underlying size-dependent maturation, mating behavior, and heterothally in pennate diatoms.

추출된 의학 개체 (NER)

시술 미세수술
해부 cell heart cells single-cell
합병증 pennate
상태/진단 SST
기타 SST
전체 NER 표 보기
유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 microsurgery 미세수술 dict 1
해부 cell scispacy 1
해부 heart scispacy 1
해부 cells scispacy 1
해부 single-cell scispacy 1
합병증 pennate scispacy 1
약물 pennate scispacy 1
질환 SST → sexual size threshold scispacy 1
기타 SST → sexual size threshold scispacy 1

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