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Clinical Durability of Hyaluronic Acid-Based Dermal Fillers for Facial Application: A Systematic Review.

Aesthetic plastic surgery 2026 Vol.50(5) p. 1971-1993

de Castro Costa M, Andrade CA, Dantas RVF, Germani M, Buzalaf MAR, Soares DG

원문 ↗ DOI ↗

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히알루론산 Hyaluronic Acid 필러 주입술 Filler Injection 안면윤곽술 Facial Bone Contouring

Abstract

[BACKGROUND] Hyaluronic acid (HA) fillers are widely regarded as safe and effective for soft tissue augmentation, including correction of nasolabial folds, wrinkles, lips, and facial contouring. Despite favorable clinical outcomes, long-term durability remains under investigation.

[OBJECTIVE] To systematically review the effects of facial HA fillers on durability, patient satisfaction, and adverse events, providing a comprehensive overview for clinical and aesthetic practice.

[METHODS] A systematic search was conducted in Virtual Health Library (BVS), Embase, PubMed, Web of Science, and Scopus for clinical and observational studies, case reports, and series reporting quantitative data with ≥12 months follow-up. Studies included patients treated with various HA formulations and focused on filler longevity, subjective satisfaction, and adverse effects.

[RESULTS] Twenty-four studies from 13 countries including 1,410 patients (81.8% female, 21-76 years) were analyzed. Nineteen HA brands were reported, with Restylane most frequent (21.1%). 3D volumetric assessments (64%) showed HA persistence of 50-86% at 24 months and 60-86.4% at 12 months, with one study reporting 6-9 months. Ultrasound (20%) indicated 12-36 months persistence; MRI (8%) and profilometry (4%) reported presence up to 12 months. Patient-reported satisfaction, measured via subjective scales, aligned with objective findings, declining alongside quantitative HA volume over time. Adverse effects were evaluated, with the majority immediate (72.6%) and long-term events rare (4.8%).

[CONCLUSION] HA filler longevity is influenced by manufacturing technology, tissue mobility, and anatomical factors. All technologies demonstrated good durability, though Vycross was associated with more long-term adverse events. Subjective satisfaction mirrored objective persistence, emphasizing the clinical relevance of both assessments. Individualized product selection remains essential to achieve safe, predictable, and satisfactory outcomes.

[LEVEL OF EVIDENCE I] This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
재료 ha 히알루론산 dict 7
재료 hyaluronic acid 히알루론산 dict 2
시술 filler 필러 주입술 dict 1
시술 ha filler 필러 주입술 dict 1
시술 facial contouring 안면윤곽술 dict 1

MeSH Terms

Humans; Dermal Fillers; Hyaluronic Acid; Skin Aging; Patient Satisfaction; Cosmetic Techniques; Female; Treatment Outcome; Esthetics; Face; Adult; Male; Middle Aged; Rejuvenation; Risk Assessment; Aged; Young Adult

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외부 PMID 23건 (DB 미수집)

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보툴리눔독소 주사 (28) 코성형술 (20) 감염 (18) 유방 (15) 지방흡입 (13) 턱끝성형술 (13) 안면거상술 (12) 피하조직 (11)

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