Investigating Sleep Concerns in Cervical Dystonia.
OpenAlex 토픽 ·
Botulinum Toxin and Related Neurological Disorders
Parkinson's Disease Mechanisms and Treatments
Neurological disorders and treatments
APA
Abhimanyu Mahajan, David Andrés González, Cynthia Comella (2026). Investigating Sleep Concerns in Cervical Dystonia.. Movement disorders clinical practice, 13(4), 1044-1049. https://doi.org/10.1002/mdc3.70393
MLA
Abhimanyu Mahajan, et al.. "Investigating Sleep Concerns in Cervical Dystonia.." Movement disorders clinical practice, vol. 13, no. 4, 2026, pp. 1044-1049.
PMID
41104575
Abstract
[BACKGROUND] Heterogenous, small cohorts, and co-occurrence of pain and psychiatric burden complicate understanding of sleep in dystonia.
[OBJECTIVE] To investigate sleep concerns in cervical dystonia (CD).
[METHODS] Longitudinal data from CD-PROBE on subjects who were toxin-naïve, new to practice, or without injections for at least 16 weeks were analyzed. Cervical Dystonia Impact Profile captured sleep disturbances. Impact of OnabotulinumtoxinA on sleep was assessed using multilevel mixed models, controlling for demographics, dystonia severity, mood, and pain.
[RESULTS] 56% (n = 1037) reported concerns with sleep initiation, restfulness, maintenance, and total time. Initial injection led to a clear improvement in sleep. (P < 0.001) Motor severity (β: 0.20, P < 0.001), mood (β: 0.36, P < 0.001), and pain (β: 0.58, P < 0.001) predicted sleep improvement (n = 502) over three OnabotulinumtoxinA cycles.
[CONCLUSIONS] Sleep concerns are common in CD, with initial and subsequent improvement with OnabotulinumtoxinA. Impact of mood and pain on sleep highlights the importance of non-motor features.
[OBJECTIVE] To investigate sleep concerns in cervical dystonia (CD).
[METHODS] Longitudinal data from CD-PROBE on subjects who were toxin-naïve, new to practice, or without injections for at least 16 weeks were analyzed. Cervical Dystonia Impact Profile captured sleep disturbances. Impact of OnabotulinumtoxinA on sleep was assessed using multilevel mixed models, controlling for demographics, dystonia severity, mood, and pain.
[RESULTS] 56% (n = 1037) reported concerns with sleep initiation, restfulness, maintenance, and total time. Initial injection led to a clear improvement in sleep. (P < 0.001) Motor severity (β: 0.20, P < 0.001), mood (β: 0.36, P < 0.001), and pain (β: 0.58, P < 0.001) predicted sleep improvement (n = 502) over three OnabotulinumtoxinA cycles.
[CONCLUSIONS] Sleep concerns are common in CD, with initial and subsequent improvement with OnabotulinumtoxinA. Impact of mood and pain on sleep highlights the importance of non-motor features.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | Cervical
|
scispacy | 1 | ||
| 해부 | non-motor
|
scispacy | 1 | ||
| 약물 | OnabotulinumtoxinA
|
scispacy | 1 | ||
| 약물 | [CONCLUSIONS] Sleep
|
scispacy | 1 | ||
| 질환 | Dystonia
|
C0013421
Dystonia
|
scispacy | 1 | |
| 질환 | pain
|
C0030193
Pain
|
scispacy | 1 | |
| 질환 | psychiatric
|
C0033873
Psychiatry Specialty
|
scispacy | 1 | |
| 질환 | sleep initiation
|
scispacy | 1 |
MeSH Terms
Humans; Torticollis; Male; Female; Middle Aged; Botulinum Toxins, Type A; Sleep Wake Disorders; Longitudinal Studies; Adult; Aged; Neuromuscular Agents; Severity of Illness Index; Pain
같은 제1저자의 인용 많은 논문 (5)
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- Therapeutic Benefit of Sensory Trick in Cervical Dystonia.
- Sensory Trick in a Patient with Cervical Dystonia: Insights from Magnetoencephalography.
- Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study.
- The Effect of Botulinum Toxin on Network Connectivity in Cervical Dystonia: Lessons from Magnetoencephalography.