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Investigating Sleep Concerns in Cervical Dystonia.
[BACKGROUND] Heterogenous, small cohorts, and co-occurrence of pain and psychiatric burden complicate understanding of sleep in dystonia. [OBJECTIVE] To investigate sleep concerns in cervical dystonia (CD). [METHODS] Longitudinal data fro…
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Understanding Anxiety in Cervical Dystonia: An Imaging Study.
[BACKGROUND] Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate. [OBJECTIVE] To investigate brain networks associated with anxi…
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The effect of botulinum toxin on anxiety in cervical dystonia: A prospective, observational study.
[INTRODUCTION] Anxiety is present in 30-40% of patients with cervical dystonia (CD). It has been ascribed to a direct effect of the state of motor symptoms on related pain, disability, and disfigurement. Accordingly, any reported benefit of…
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Therapeutic Benefit of Sensory Trick in Cervical Dystonia.
[BACKGROUND] Sensory tricks (STs) are voluntary maneuvers that dampen the abnormal movement in cervical dystonia (CD). [OBJECTIVES] To investigate the effect of ST on CD severity and treatment. [METHODS] Data on 1039 individuals with a mo…
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Efficacy and safety of two incobotulinumtoxinA injection intervals in cervical dystonia patients with inadequate benefit from standard injection intervals of botulinum toxin: Phase 4, open-label, randomized, noninferiority study.
[UNLABELLED] IntroductionSome patients with cervical dystonia (CD) receiving long-term botulinum neurotoxin (BoNT) therapy report early waning of treatment benefit before the typical 12-week reinjection interval. [METHODS] This phase 4, op…
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Patient perspectives on the therapeutic profile of botulinum neurotoxin type A in cervical dystonia.
[BACKGROUND] Botulinum neurotoxin type A (BoNT-A) is an effective pharmacological treatment for the management of cervical dystonia (CD) that requires repeated administration at variable intervals. We explored patient perceptions of the imp…
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An Open-Label Phase 2a Study to Evaluate the Safety and Tolerability of Perampanel in Cervical Dystonia.
[BACKGROUND] Cervical dystonia (CD) is the most common focal isolated dystonia. Preclinical studies report that AMPA-selective glutamate receptor antagonists improve dystonia. Perampanel is a clinically available, AMPA receptor antagonist t…
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Injectable DaxibotulinumtoxinA in Cervical Dystonia: A Phase 2 Dose-Escalation Multicenter Study.
[BACKGROUND] Injectable daxibotulinumtoxinA (an investigational botulinum toxin, RT002) may offer a more prolonged duration of response-and therefore less frequent dosing-than onabotulinumtoxinA. [OBJECTIVES] To perform a phase 2, open-lab…
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Minimal clinically important change in the Toronto Western Spasmodic Torticollis Rating Scale.
[OBJECTIVES] To characterize the minimal clinically important change (MCIC) after treatment in cervical dystonia patients using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). [METHODS] Changes in the TWSTRS from an observ…
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Considerations on patient-related outcomes with the use of botulinum toxins: is switching products safe?
[INTRODUCTION] Botulinum toxin (BoNT) is the treatment of choice for many neurologic movement disorders, including blepharospasm, hemifacial spasm, and cervical dystonia. There are two serotypes approved for use by the US Food and Drug Admi…