Human breast epithelial xenografts: an immunocytochemical and ultrastructural study of differentiation and lactogenic response.
Abstract
Fragments of ductal and lobular epithelium ('organoids') produced by collagenase digestion of reduction-mammoplasty specimens were injected into athymic 'nude' mice. These heterospecific tissues were accepted without rejection, and the presence of xenografts was confirmed by cytology, immunocytochemistry and chromatin staining. Lactation, as confirmed by immunocytochemical and ultrastructural criteria, was observed in the grafted human epithelium during murine pregnancy at both intra- and extra-mammary sites.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | mammoplasty
|
유방성형술 | dict | 1 | |
| 해부 | breast
|
유방 | dict | 1 | |
| 해부 | mammary
|
유방 | dict | 1 | |
| 해부 | lobular epithelium
|
scispacy | 1 | ||
| 해부 | chromatin
|
scispacy | 1 | ||
| 해부 | Lactation
|
scispacy | 1 | ||
| 합병증 | extra-mammary sites
|
scispacy | 1 | ||
| 질환 | extra-mammary
|
scispacy | 1 | ||
| 질환 | ductal
|
scispacy | 1 | ||
| 질환 | specimens
|
scispacy | 1 | ||
| 질환 | xenografts
|
scispacy | 1 | ||
| 기타 | Human breast epithelial xenografts
|
scispacy | 1 | ||
| 기타 | collagenase
|
scispacy | 1 | ||
| 기타 | athymic 'nude' mice
|
scispacy | 1 | ||
| 기타 | human epithelium
|
scispacy | 1 | ||
| 기타 | murine pregnancy
|
scispacy | 1 |
MeSH Terms
Actins; Adult; Animals; Antibodies, Monoclonal; Breast; Cell Differentiation; Cell Nucleus; Chromatin; Collagen; Epithelium; Female; Humans; Keratins; Mice; Mice, Nude; Microscopy, Electron; Pregnancy; Transplantation, Heterologous
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