Androgens and androgen receptor action in skin and hair follicles.
💡 한 문장 핵심
피부와 모낭에서 안드로겐 및 안드로겐 수용체의 작용.
5/5 보강
TL;DR
The molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrine factors deregulated in dermal papillae and the crosstalk between AR and Wnt signaling are reviewed in order to shed some light on new promising treatments.
📑 코퍼스 인용 관계
· 인용됨 41
📑 인용한 논문 (6) ▾
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연도별 인용 (2018–2026) · 합계 207
OpenAlex 토픽 ·
Hair Growth and Disorders
Cancer and Skin Lesions
melanin and skin pigmentation
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
피부와 모낭에서 안드로겐(androgen) 및 안드로겐 수용체(androgen receptor, AR)의 작용 기전을 정리하고, 특히 안드로겐성 탈모(androgenetic alopecia, AGA)에서의 분자 병태생리를 규명하여 새로운 치료 표적을 모색하고자 함.
【방법】
피부 스테로이드 생성(steroidogenesis) 관련 효소, 제2형 5알파-환원효소(type 2 5α-reductase), AR 보조활성인자(coactivator), 모유두(dermal papilla)에서 분비되는 측분비 인자(TGF-β, IGF-1, WNTs, DKK-1) 및 AR–Wnt 신호 교차작용(crosstalk)에 관한 최신 연구들을 종합 고찰함.
【주요 결과】
피부 세포는 생식선·부신 전구체로부터 활성 안드로겐을 자체 합성할 수 있으며, AGA에서는 모유두 내 TGF-β·DKK-1 증가와 IGF-1·Wnt 신호 감소가 모낭 위축을 유발함. AR–Wnt 신호 교차작용이 모낭 성장기(anagen) 유지의 핵심 분자 기전으로 확인됨.
【임상적 시사점 (성형외과 의사 관점)】
기존 5알파-환원효소 억제제(피나스테리드/두타스테리드) 외에, AR 보조활성인자 차단 및 Wnt 신호 활성화·DKK-1 억제를 표적으로 하는 차세대 탈모 치료제 개발 가능성을 시사함. 모발이식 시 공여부 모낭의 AR 감수성과 모유두 측분비 환경을 고려하면 비수술적 보조 치료와의 병용 전략(예: 엑소좀·성장인자 주입)을 통해 생착률과 장기 유지율을 개선할 수 있음.
Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA). We review the molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrine factors deregulated in dermal papillae (such as TGF-β, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments.
【연구 목적】 피부와 모낭에서 안드로겐(androgen) 및 안드로겐 수용체(androgen receptor, AR)의 작용 기전을 정리하고, 특히 안드로겐성 탈모(androgenetic alopecia, AGA)에서의 분자 병태생리를 규명하여 새로운 치료 표적을 모색하고자 함.
APA 7
Ceruti, J. M., GJ, L., & ME, B. (2018). Androgens and androgen receptor action in skin and hair follicles.. Molecular and cellular endocrinology, 465, 122-133. https://doi.org/10.1016/j.mce.2017.09.009
Vancouver
Ceruti JM, GJ L, ME B. Androgens and androgen receptor action in skin and hair follicles. Mole. cell. endo.. 2018;465:122-133. doi:10.1016/j.mce.2017.09.009
AMA 11
Ceruti JM, GJ L, ME B. Androgens and androgen receptor action in skin and hair follicles. Mole. cell. endo.. 2018;465:122-133. doi:10.1016/j.mce.2017.09.009
Chicago
Ceruti, J. M., GJ, L., and ME, B.. 2018. "Androgens and androgen receptor action in skin and hair follicles." Molecular and cellular endocrinology 465: 122-133. https://doi.org/10.1016/j.mce.2017.09.009
MLA 9
Ceruti, J. M., et al. "Androgens and androgen receptor action in skin and hair follicles." Molecular and cellular endocrinology, vol. 465, 2018, pp. 122-133. doi:10.1016/j.mce.2017.09.009.
PMID
28912032 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 1 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 1 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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