Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.
💡 한 문장 핵심
안드로겐성 탈모 남성의 모유두세포에서 나타나는 산화 스트레스 관련 노화.
5/5 보강
TL;DR
In vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.
📑 코퍼스 인용 관계
· 인용됨 70 · 인용함 55
→ 이 논문이 인용한 논문 (4) ▾
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- Induction of hair growth by implantation of cultured dermal papilla cells. Nature · 1984
- Male pattern baldness: classification and incidence. Southern medical journal · 1975
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연도별 인용 (2013–2026) · 합계 223
OpenAlex 토픽 ·
Skin Protection and Aging
Hair Growth and Disorders
Telomeres, Telomerase, and Senescence
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
남성형 탈모(androgenetic alopecia, AGA) 환자의 모유두세포(dermal papilla cells, DPCs)에서 관찰되는 조기 세포노화 현상이 산화 스트레스(oxidative stress)와 어떤 연관이 있는지, 그리고 이것이 탈모 병인에 기여하는지를 규명하고자 함.
【방법】
동일 환자의 탈모 부위(전두부) 두피와 비탈모 부위(후두부) 두피에서 채취한 모유두세포를 대기 중 산소 농도(21%)와 생리학적 산소 농도(2%) 환경에서 각각 배양하여 형태, 이동성, 활성산소(ROS), 노화 표지자(p16INK4a, pRB, SA-β-Gal), 항산화 효소(catalase, glutathione), 모발 성장 억제 인자(TGF-β1, TGF-β2) 분비를 비교 분석함.
【주요 결과】
21% 산소 환경에서 탈모 부위 DPCs는 후두부 세포 대비 편평한 형태, 이동성 저하, ROS 및 노화 표지자 증가를 보였고, H2O2 자극 시 TGF-β1·β2 분비가 유의하게 증가함. 탈모 부위 DPCs는 catalase와 총 glutathione 수치는 더 높았으나, 산화 스트레스 대응 능력은 오히려 떨어지는 역설적 양상을 보임.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation) 시 후두부 공여부 모낭이 탈모 부위 모낭보다 산화 스트레스 저항성이 우수하다는 분자생물학적 근거를 제공하여 donor dominance 이론을 뒷받침함. AGA 치료 및 모발이식 전후 보조요법으로 항산화제(국소 또는 경구) 및 TGF-β 억제 전략의 병용을 고려해볼 수 있으며, PRP·엑소좀 시술 시 산화 스트레스 감소 효과를 환자 상담에 활용할 수 있음.
Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo premature senescence in vitro in association with the expression of p16(INK4a), suggesting that DPCs from balding scalp are more sensitive to environmental stress than nonbalding cells. As one of the major triggers of senescence in vitro stems from the cell "culture shock" owing to oxidative stress, we have further investigated the effects of oxidative stress on balding and occipital scalp DPCs. Patient-matched DPCs from balding and occipital scalp were cultured at atmospheric (21%) or physiologically normal (2%) O2. At 21% O2, DPCs showed flattened morphology and a significant reduction in mobility, population doubling, increased levels of reactive oxygen species and senescence-associated β-Gal activity, and increased expression of p16(INK4a) and pRB. Balding DPCs secreted higher levels of the negative hair growth regulators transforming growth factor beta 1 and 2 in response to H2O2 but not cell culture-associated oxidative stress. Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs. These in vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.
【연구 목적】 남성형 탈모(androgenetic alopecia, AGA) 환자의 모유두세포(dermal papilla cells, DPCs)에서 관찰되는 조기 세포노화 현상이 산화 스트레스(oxidative stress)와 어떤 연관이 있는지, 그리고 이것이 탈모 병인에 기여하는지를 규명하고자 함.
APA 7
Upton, J. H., Hannen, R. F., Bahta, A. W., Farjo, N., Farjo, B., & Philpott, M. P. (2015). Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.. The Journal of investigative dermatology, 135(5), 1244-1252. https://doi.org/10.1038/jid.2015.28
Vancouver
Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. Jour. inve. derm.. 2015;135(5):1244-1252. doi:10.1038/jid.2015.28
AMA 11
Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. Jour. inve. derm.. 2015;135(5):1244-1252. doi:10.1038/jid.2015.28
Chicago
Upton, J. H., Hannen, R. F., Bahta, A. W., Farjo, N., Farjo, B., and Philpott, M. P.. 2015. "Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia." The Journal of investigative dermatology 135 (5): 1244-1252. https://doi.org/10.1038/jid.2015.28
MLA 9
Upton, J. H., et al. "Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia." The Journal of investigative dermatology, vol. 135, no. 5, 2015, pp. 1244-1252. doi:10.1038/jid.2015.28.
PMID
25647436 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | scalp
|
두피 | dict | 3 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🤖 이 논문을 인용한 AI 인사이트 · 4건
🧮 메타후보
🏷 기초·실험
모발 줄기세포 이동 — 통합 시기상조
P: 사람 모낭 유래 세포(DPC/keratinocyte) 등 모발 줄기세포를 대상으로 한 in vitro 연구. 현 근거는 종·모델(생체/배양)이 O: 표준화된 세포 이동 정량지표(scratch/transwell migration rate, 표준화 평균차 SMD). 부수적으로 clonogenic
🧮 메타후보
🏷 기초·실험
모낭 세포이동 — 통합분석 시기상조
P: 모낭 및 피부 관련 줄기세포·표피 모델, 상처 치유 동물모델, 안드로젠성 탈모(AGA)의 모유두세포(DPC) 등 종·모델이 이질적인 집단입니다. O: 표준화된 in vivo 세포이동 속도(migration velocity), 상처 재상피화율(re-epithelialization rate) 등
🧮 메타후보
🏷 기초·실험
탈모·모낭 세포이동 — 통합 미성숙
P: 탈모·모낭 연구 모델로, 주로 동물모델(mouse)의 vibrissa/tail 조직 세포와 in vitro 진피유두세포가 대상이며, 인간(예: O: 세포 이동 속도·이동거리, 재상피화 시간, 모발밀도, 클론원성, 노화마커(senescence) 등 이질적인 세포 mobility·기능 지표입니다
🧮 메타후보
🏷 기초·실험
탈모 세포이동 — 통합 시기상조
P: 탈모 환자 및 모델로, androgenetic alopecia·alopecia areata 같은 임상 질환과 마우스 lineage tracing O: 모발 밀도, 재성장률, 세포 노화 marker 및 면역조직학적 TRM cell 분포 등 이질적 지표입니다.
이 논문은 위 AI 빅데이터 분석에 인용된 근거 논문입니다.
인용 관계
그래프 OA 노드: 9/12 (75%)
· 참조 1편 · 후속 8편
이 논문이 참조한 문헌 34
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외부 PMID 30건 (DB 미수집)
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이 논문을 인용한 후속 연구 20
- Androgenetic alopecia: a review.
- Tissue engineering of human hair follicles using a biomimetic developmental approach.
- Diet and hair loss: effects of nutrient deficiency and supplement use.
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- Scalp Condition Impacts Hair Growth and Retention via Oxidative Stress.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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