Prognostic Significance of Deubiquitinase OTUD7B in NK/T-Cell Lymphoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: OTUD7B overexpression exhibit improved progression-free survival (PFS) (p = 0
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Multivariate Cox regression analysis demonstrated that OTUD7B was an independent prognostic indicator for both PFS (p = 0.037, HR = 0.401, 95% CI: 0.169-0.947) and OS (p = 0.043, HR = 0.278, 95% CI: 0.081-0.961) in NTKCL patients. [CONCLUSION] OTUD7B could act as a prognostic indicator in NTKCL patients; further investigations remain imperative.
[AIM] OTUD7B (ovarian tumor domain-containing 7B) is a deubiquitinase that has established prognostic significance in diffuse large B-cell lymphoma and various solid tumors.
- p-value p = 0.021
- p-value p = 0.007
- 95% CI 0.169-0.947
- HR 0.401
APA
Liu Y, Wen S, et al. (2025). Prognostic Significance of Deubiquitinase OTUD7B in NK/T-Cell Lymphoma.. Asia-Pacific journal of clinical oncology. https://doi.org/10.1111/ajco.70060
MLA
Liu Y, et al.. "Prognostic Significance of Deubiquitinase OTUD7B in NK/T-Cell Lymphoma.." Asia-Pacific journal of clinical oncology, 2025.
PMID
41283788 ↗
Abstract 한글 요약
[AIM] OTUD7B (ovarian tumor domain-containing 7B) is a deubiquitinase that has established prognostic significance in diffuse large B-cell lymphoma and various solid tumors. In our present work, we aimed to explore its role in NK/T cell lymphoma (NKTCL).
[METHODS] Expression level of OTUD7B was assessed through immunohistochemistry in 53 NKTCL tissue samples. Statistical analyses were conducted to elucidate correlations between its expression and clinicopathological parameters of patients. Kaplan-Meier survival curves were constructed for survival analyses.
[RESULTS] OTUD7B was overexpressed in 41 (77.4%) NK/T tissue samples. Remarkably, patients with OTUD7B overexpression exhibit improved progression-free survival (PFS) (p = 0.021) and overall survival (OS) compared to those with low OTUD7B expression (p = 0.007). Multivariate Cox regression analysis demonstrated that OTUD7B was an independent prognostic indicator for both PFS (p = 0.037, HR = 0.401, 95% CI: 0.169-0.947) and OS (p = 0.043, HR = 0.278, 95% CI: 0.081-0.961) in NTKCL patients.
[CONCLUSION] OTUD7B could act as a prognostic indicator in NTKCL patients; further investigations remain imperative.
[METHODS] Expression level of OTUD7B was assessed through immunohistochemistry in 53 NKTCL tissue samples. Statistical analyses were conducted to elucidate correlations between its expression and clinicopathological parameters of patients. Kaplan-Meier survival curves were constructed for survival analyses.
[RESULTS] OTUD7B was overexpressed in 41 (77.4%) NK/T tissue samples. Remarkably, patients with OTUD7B overexpression exhibit improved progression-free survival (PFS) (p = 0.021) and overall survival (OS) compared to those with low OTUD7B expression (p = 0.007). Multivariate Cox regression analysis demonstrated that OTUD7B was an independent prognostic indicator for both PFS (p = 0.037, HR = 0.401, 95% CI: 0.169-0.947) and OS (p = 0.043, HR = 0.278, 95% CI: 0.081-0.961) in NTKCL patients.
[CONCLUSION] OTUD7B could act as a prognostic indicator in NTKCL patients; further investigations remain imperative.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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