Prognostic implication of serum levels of IL-6 and IL-10 in children and adolescents with aggressive mature B-cell non-Hodgkin lymphoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
139 patients aged < 18 years with newly diagnosed mature B-NHL were enrolled.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Our study suggests that elevated serum IL-6 and IL-10 levels at diagnosis are associated with poor prognosis in pediatric mature B-NHL and may have the potential to inform risk stratification.
[BACKGROUND] Aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) is the most common subtype of non-Hodgkin lymphoma in children and adolescents.
- 표본수 (n) 35
- p-value p = 0.01
- p-value p = 0.02
APA
Zeng C, Wei Z, et al. (2025). Prognostic implication of serum levels of IL-6 and IL-10 in children and adolescents with aggressive mature B-cell non-Hodgkin lymphoma.. BMC cancer, 26(1), 13. https://doi.org/10.1186/s12885-025-15377-1
MLA
Zeng C, et al.. "Prognostic implication of serum levels of IL-6 and IL-10 in children and adolescents with aggressive mature B-cell non-Hodgkin lymphoma.." BMC cancer, vol. 26, no. 1, 2025, pp. 13.
PMID
41299342 ↗
Abstract 한글 요약
[BACKGROUND] Aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) is the most common subtype of non-Hodgkin lymphoma in children and adolescents. However, little progress has been made in determining the prognostic factors of children and adolescents with B-NHL. Based on the effect of cytokines in other cancer types, this study explored the effect of cytokines on the prognosis of children and adolescents with B-NHL.
[METHODS] The levels of serum cytokines including interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were detected at diagnosis. Correlations between cytokines, clinical characteristics, and treatment outcomes were retrospectively analyzed.
[RESULTS] In total, 139 patients aged < 18 years with newly diagnosed mature B-NHL were enrolled. Patients with elevated IL-6 levels at diagnosis (n = 35) had worse 5-year event-free survival (85.3% vs. 97.1%, p = 0.01) and overall survival (OS) rates (91.2% vs. 99.0%, p = 0.02) than those with normal IL-6 levels. Patients with elevated IL-10 (n = 35) had worse 5-year OS rates (91.4% vs. 99.0%, p = 0.02) than those with normal IL-10 levels. Cox multivariate analysis identified elevated IL-6 levels at diagnosis as an independent adverse prognostic factor in pediatric B-NHL. Elevated IL-6 levels correlated positively with IL-10 levels, and patients with simultaneously elevated IL-6 and IL-10 levels had the worst prognosis in the entire cohort.
[CONCLUSIONS] Our study suggests that elevated serum IL-6 and IL-10 levels at diagnosis are associated with poor prognosis in pediatric mature B-NHL and may have the potential to inform risk stratification. Future prospective, multi-center studies are required to validate these findings.
[METHODS] The levels of serum cytokines including interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were detected at diagnosis. Correlations between cytokines, clinical characteristics, and treatment outcomes were retrospectively analyzed.
[RESULTS] In total, 139 patients aged < 18 years with newly diagnosed mature B-NHL were enrolled. Patients with elevated IL-6 levels at diagnosis (n = 35) had worse 5-year event-free survival (85.3% vs. 97.1%, p = 0.01) and overall survival (OS) rates (91.2% vs. 99.0%, p = 0.02) than those with normal IL-6 levels. Patients with elevated IL-10 (n = 35) had worse 5-year OS rates (91.4% vs. 99.0%, p = 0.02) than those with normal IL-10 levels. Cox multivariate analysis identified elevated IL-6 levels at diagnosis as an independent adverse prognostic factor in pediatric B-NHL. Elevated IL-6 levels correlated positively with IL-10 levels, and patients with simultaneously elevated IL-6 and IL-10 levels had the worst prognosis in the entire cohort.
[CONCLUSIONS] Our study suggests that elevated serum IL-6 and IL-10 levels at diagnosis are associated with poor prognosis in pediatric mature B-NHL and may have the potential to inform risk stratification. Future prospective, multi-center studies are required to validate these findings.
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