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Hidden Malignancy: Ileocecal Intussusception as an Atypical First Presentation of Diffuse Large B-cell Lymphoma in Adulthood.

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Journal of community hospital internal medicine perspectives 2026 Vol.16(1) p. 56-59 OA
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Harisinghani K, Adrejiya P, Abubaker M, Idenyi O, Babayeuski R, Qureshi N

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Intussusception is predominantly a pediatric condition, with only about 5 % of all intussusception cases occurring in adults with primary intestinal lymphomas comprising 1 %-4 % of gastrointestinal ma

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APA Harisinghani K, Adrejiya P, et al. (2026). Hidden Malignancy: Ileocecal Intussusception as an Atypical First Presentation of Diffuse Large B-cell Lymphoma in Adulthood.. Journal of community hospital internal medicine perspectives, 16(1), 56-59. https://doi.org/10.55729/2000-9666.1567
MLA Harisinghani K, et al.. "Hidden Malignancy: Ileocecal Intussusception as an Atypical First Presentation of Diffuse Large B-cell Lymphoma in Adulthood.." Journal of community hospital internal medicine perspectives, vol. 16, no. 1, 2026, pp. 56-59.
PMID 41809228 ↗

Abstract

Intussusception is predominantly a pediatric condition, with only about 5 % of all intussusception cases occurring in adults with primary intestinal lymphomas comprising 1 %-4 % of gastrointestinal malignancies, 90 % of which are B-cell non-Hodgkin lymphomas (NHL). Diffuse large B-cell lymphoma (DLBCL), the most common subtype of NHL, often leads to intussusception without classical B symptoms. We present the case of a 33-year-old male with ileocolonic intussusception caused by a 4.8 × 5.3 × 5.5 cm enhancing mass. Histopathology and FISH confirmed DLBCL without MYC, BCL2, or BCL6 rearrangements, ruling out double- or triple-hit lymphoma. Following a right ileo-colectomy, R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy was initiated. This case underscores the role of malignancy in intussusception and highlights the importance of timely diagnosis and management.

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