Comparison of frozen embryo transfer outcomes in hormonal vs. mild stimulation protocols in polycystic ovary syndrome women: A randomized controlled trial.
무작위 임상시험
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
HRT and MOS in infertile women with PCOS.
I · Intervention 중재 / 시술
in both groups, and pregnancy outcomes (chemical, clinical, and final) were compared
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
However, the number of clinical pregnancies (p = 0.045) and the number of successful pregnancies (p = 0.049) were significantly higher in the MOS group compared to the HRT group. [CONCLUSION] This study showed that MOS achieved higher clinical and successful pregnancy rates than HRT in women with PCOS.
[BACKGROUND] Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility.
- p-value p = 0.078
- p-value p = 0.045
APA
Hamdi K, Khakpour S, et al. (2025). Comparison of frozen embryo transfer outcomes in hormonal vs. mild stimulation protocols in polycystic ovary syndrome women: A randomized controlled trial.. International journal of reproductive biomedicine, 23(12), 995-1006. https://doi.org/10.18502/ijrm.v23i12.20712
MLA
Hamdi K, et al.. "Comparison of frozen embryo transfer outcomes in hormonal vs. mild stimulation protocols in polycystic ovary syndrome women: A randomized controlled trial.." International journal of reproductive biomedicine, vol. 23, no. 12, 2025, pp. 995-1006.
PMID
41783725 ↗
Abstract 한글 요약
[BACKGROUND] Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility. In women undergoing frozen embryo transfer, the method of endometrial preparation (hormone replacement therapy [HRT] or mild ovarian stimulation [MOS]) can affect pregnancy outcomes. Letrozole-based MOS protocols may improve endometrial receptivity and reduce miscarriage rates by upregulating key implantation markers leukemia inhibitory factor dickkopf-related protein 1 leukemia inhibitory factor receptor fibroblast growth factor 22 integrin alpha V beta 3.
[OBJECTIVE] This study aimed to compare the frozen embryo transfer outcomes in 2 endometrial preparation methods: HRT and MOS in infertile women with PCOS.
[MATERIALS AND METHODS] This double-blind randomized trial included 100 infertile women with PCOS and frozen embryos who referred to Al-Zahra hospital, Tabriz, Iran between October 2024 and 2025. Participants were assigned to HRT or MOS for endometrial preparation. In HRT, oral estradiol followed by injectable progesterone was used; in MOS, letrozole + follicle-stimulating hormone stimulation continued until follicle 17 mm and endometrium 7.5 mm, then human chorionic gonadotropin was given. Cleavage-stage transfer was performed in both groups, and pregnancy outcomes (chemical, clinical, and final) were compared.
[RESULTS] The number of transferred embryos (p = 0.771) and their quality (types 1 and 2) (p = 0.857) were similar between groups. The number of chemical pregnancies in the MOS group (25 cases) was non-significantly higher than in the HRT group (20 cases) (p = 0.078). However, the number of clinical pregnancies (p = 0.045) and the number of successful pregnancies (p = 0.049) were significantly higher in the MOS group compared to the HRT group.
[CONCLUSION] This study showed that MOS achieved higher clinical and successful pregnancy rates than HRT in women with PCOS.
[OBJECTIVE] This study aimed to compare the frozen embryo transfer outcomes in 2 endometrial preparation methods: HRT and MOS in infertile women with PCOS.
[MATERIALS AND METHODS] This double-blind randomized trial included 100 infertile women with PCOS and frozen embryos who referred to Al-Zahra hospital, Tabriz, Iran between October 2024 and 2025. Participants were assigned to HRT or MOS for endometrial preparation. In HRT, oral estradiol followed by injectable progesterone was used; in MOS, letrozole + follicle-stimulating hormone stimulation continued until follicle 17 mm and endometrium 7.5 mm, then human chorionic gonadotropin was given. Cleavage-stage transfer was performed in both groups, and pregnancy outcomes (chemical, clinical, and final) were compared.
[RESULTS] The number of transferred embryos (p = 0.771) and their quality (types 1 and 2) (p = 0.857) were similar between groups. The number of chemical pregnancies in the MOS group (25 cases) was non-significantly higher than in the HRT group (20 cases) (p = 0.078). However, the number of clinical pregnancies (p = 0.045) and the number of successful pregnancies (p = 0.049) were significantly higher in the MOS group compared to the HRT group.
[CONCLUSION] This study showed that MOS achieved higher clinical and successful pregnancy rates than HRT in women with PCOS.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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