Clinical characteristics and complications in children and adolescents with hyperleukocytic acute leukemia.
단면연구
2/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
Descriptive, retrospective, cross-sectional study conducted in a tertiary pediatric hospital between January 1, 2020, and December 31, 2024.
I · Intervention 중재 / 시술
rasburicase, and 1/3 required leukapheresis; 90% began chemotherapy within the first 2 days of hospitalization
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The importance of early diagnosis and intensive initial management to improve the clinical outcomes of these high-risk patients is highlighted.
OpenAlex 토픽 ·
Acute Lymphoblastic Leukemia research
Acute Myeloid Leukemia Research
Neutropenia and Cancer Infections
Introduction.
- 연구 설계 cross-sectional
APA
Belén A Insaurralde, Julieta Marín, et al. (2026). Clinical characteristics and complications in children and adolescents with hyperleukocytic acute leukemia.. Archivos argentinos de pediatria, e202510914. https://doi.org/10.5546/aap.2025-10914.eng
MLA
Belén A Insaurralde, et al.. "Clinical characteristics and complications in children and adolescents with hyperleukocytic acute leukemia.." Archivos argentinos de pediatria, 2026, pp. e202510914.
PMID
41979386 ↗
Abstract 한글 요약
Introduction. Hyperleukocytic acute leukemia is a pediatric hematological-oncological emergency associated with high morbidity and mortality. Objective. To describe the clinical and hematological characteristics, complications, and treatments of patients with acute hyperleukocytic lymphoblastic or myeloid leukemia. Population and methods. Descriptive, retrospective, cross-sectional study conducted in a tertiary pediatric hospital between January 1, 2020, and December 31, 2024. Results. Twenty-one patients <15 years of age diagnosed with hyperleukocytic leukemia were analyzed. Fifty-six percent had type B acute lymphoblastic leukemia, and 62% had extramedullary manifestations such as hepatomegaly and splenomegaly. The most common complications were tumor lysis syndrome (71%) and leukostasis (28%); 76% received rasburicase, and 1/3 required leukapheresis; 90% began chemotherapy within the first 2 days of hospitalization. There was a single early death due to hemorrhage in the central nervous system. Conclusion. The importance of early diagnosis and intensive initial management to improve the clinical outcomes of these high-risk patients is highlighted.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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