Anti-leukemia steroidal saponins from Paris polyphylla var. yunnanensis.
2/5 보강
TL;DR
Compound 9 likely induces tumor cell apoptosis and inhibits cell cycle progression via targeting the PI3K/AKT/GSK3β signaling pathway, providing critical molecular evidence for the development of target-specific anti-leukemia therapeutics.
OpenAlex 토픽 ·
Phytochemical Studies and Bioactivities
Magnolia and Illicium research
Natural product bioactivities and synthesis
Compound 9 likely induces tumor cell apoptosis and inhibits cell cycle progression via targeting the PI3K/AKT/GSK3β signaling pathway, providing critical molecular evidence for the development of targ
APA
Yu Zhang, Yu-Chen Zhang, et al. (2026). Anti-leukemia steroidal saponins from Paris polyphylla var. yunnanensis.. Phytochemistry, 245, 114787. https://doi.org/10.1016/j.phytochem.2026.114787
MLA
Yu Zhang, et al.. "Anti-leukemia steroidal saponins from Paris polyphylla var. yunnanensis.." Phytochemistry, vol. 245, 2026, pp. 114787.
PMID
41580063 ↗
Abstract 한글 요약
From the rhizomes of Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz., five novel steroidal saponins (Polyphyllozsides A-E, 1-5) and four known steroidal saponins (6-9) were isolated. The biological activities of the nine compounds against human hematologic malignancy cell lines (U-937, THP-1 and Jurkat) was evaluated using a cytotoxicity assay. The results demonstrated that compound 9 significantly inhibited the proliferation of Jurkat cells, with an IC value of 0.25 ± 0.03 μM. Compound 9 likely induces tumor cell apoptosis and inhibits cell cycle progression via targeting the PI3K/AKT/GSK3β signaling pathway, providing critical molecular evidence for the development of target-specific anti-leukemia therapeutics.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Saponins
- Cell Proliferation
- Antineoplastic Agents
- Phytogenic
- Drug Screening Assays
- Antitumor
- Steroids
- Apoptosis
- Liliaceae
- Rhizome
- Leukemia
- Molecular Structure
- Cell Line
- Tumor
- Structure-Activity Relationship
- Dose-Response Relationship
- Drug
- Jurkat Cells
- Melanthiaceae
- Anti-leukemia
- Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz.
- Steroidal saponins
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