Epigenetic silencing promotes pancreatic cancer growth by activating Wnt signaling.

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 () is a new member of the SCAN domain family. The expression regulation and biological function remain to be elucidated. In this study, we explored the epigenetic regulation and the function of in PDAC. was methylated in 60.21% (171/284) of PDAC and its expression was regulated by promoter region methylation. The expression of inhibited cell proliferation, colony formation, migration, invasion, and induced apoptosis and G1/S phase arrest. suppressed Panc10.05 cell xenograft growth in mice. Mechanistically, inhibited Wnt signaling by interacting with myosin heavy chain 9 (MYH9) in pancreatic cancer cells. is frequently methylated in PDAC and may serve as a detective marker. suppresses PDAC cell growth both and .