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10건- Osteosclerotic changes on computed tomography as a prognostic biomarker in prostate cancer with bone metastases: insights and future directions.
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Development and Validation of an Instrument to Measure Intention of Cancer Surveillance Among Patients With Hereditary Colorectal Cancer on the Basis of Theory of Planned Behavior.
[OBJECTIVE] Patients with hereditary colorectal cancer (HCRC) require consistent surveillance for both intestinal and extra-intestinal cancers. This study aims to develop a scale to measure variables associated with the intention of cancer …
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Targeting CAFs-derived PCSK6 inhibits redistribution of PD-L1 and restores response of CD8T cells against colorectal cancer.
Carcinoma-associated fibroblasts (CAFs) are core components of the tumor microenvironment, which contribute to tumor initiation and progression through mediating immune suppression. In this study, eight activated CAF subpopulations were ide…
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Tenascin C Enhances the Development of Papillary Thyroid Carcinoma and has Diagnostic Significance in Papillary Thyroid Microcarcinoma.
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, a subtype of which is papillary thyroid microcarcinoma (PTMC). Tenascin C (TNC) is associated with the proliferation and metastasis of medullary thyroid cancer cel…
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Visit‑to‑visit variability of inflammation-immunity indices and prognosis in hepatocellular carcinoma.
[BACKGROUND] Inflammatory–immune blood indices such as the systemic immune‑inflammation index (SII) relate to outcomes in hepatocellular carcinoma (HCC). Visit‑to‑visit variability (VVV) may capture instability of host inflammatory homeosta…
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Identification of pancreatic adenocarcinoma immune subtype associated with tumor neoantigen from aberrant alternative splicing.
[BACKGROUND] Pancreatic adenocarcinoma (PAAD) is referred to as an immunologically "cold" tumor that responds poorly to immunotherapy. A fundamental theory that explains the low immunogenicity of PAAD is the dramatically low tumor mutation …
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Epigenetic silencing promotes pancreatic cancer growth by activating Wnt signaling.
Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 () is a new member of the SCAN domain family. The expression regulation and biological function remain to be elucidated. …
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LncRNA ARAP1-AS1 targets miR-516b-5p/PDE5A axis to facilitate the progression of thyroid cancer.
Thyroid cancer (TC) remains a prevalent public health concern. To further study the molecular mechanism of TC development, we explored the regulatory mechanism and function of lncRNA ARAP1-AS1 in TC progression. The verification of ARAP1-AS…
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Research progress of plant-derived natural products in thyroid carcinoma.
Thyroid carcinoma (TC) is a prevalent malignancy of the endocrine system, with a notable rise in its detection rate in recent decades. The primary therapeutic approaches for TC now encompass thyroidectomy and radioactive iodine therapy, yie…
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A metabolism-related gene signature for predicting the prognosis in thyroid carcinoma.
Metabolic reprogramming is one of the cancer hallmarks, important for the survival of malignant cells. We investigated the prognostic value of genes associated with metabolism in thyroid carcinoma (THCA). A prognostic risk model of metaboli…