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Application of Early Dynamic F-FDG PET/CT in T1 and T2 Cervical Cancer.

Clinical radiology 2025 Vol.83() p. 106816

Cui Y, Zhou W, Zhang B, Li F, Lv Y

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[AIM] Early 10-minute dynamic F18-fluorodeoxyglucose positron emission tomography/computed tomography (ED F-FDG PET/CT) can assess blood flow characteristics in cancers such as hepatocellular carcinom

🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • 표본수 (n) 26
  • p-value P < 0.05

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BibTeX ↓ RIS ↓
APA Cui Y, Zhou W, et al. (2025). Application of Early Dynamic F-FDG PET/CT in T1 and T2 Cervical Cancer.. Clinical radiology, 83, 106816. https://doi.org/10.1016/j.crad.2025.106816
MLA Cui Y, et al.. "Application of Early Dynamic F-FDG PET/CT in T1 and T2 Cervical Cancer.." Clinical radiology, vol. 83, 2025, pp. 106816.
PMID 39954597
DOI 10.1016/j.crad.2025.106816

Abstract

[AIM] Early 10-minute dynamic F18-fluorodeoxyglucose positron emission tomography/computed tomography (ED F-FDG PET/CT) can assess blood flow characteristics in cancers such as hepatocellular carcinoma, pancreatic cancer and bladder cancer. However, its application in cervical cancer detection is unexplored. This study evaluated the role of ED F-FDG PET/CT in detecting cervical cancer and the correlation between maximum standardized uptake value (SUVmax) and tumour-to-background ratio (TBR) in patients with stages T1 and T2 cervical cancer.

[MATERIALS AND METHODS] Twenty-six patients with confirmed cervical cancer underwent both ED F-FDG PET/CT and 60-minute static whole-body F-FDG PET/CT (WB F-FDG PET/CT). SUVmax and TBR of cervical cancer lesions were compared between stages T1 and T2.

[RESULTS] ED F-FDG PET/CT demonstrated 100% sensitivity (n = 26/26) in detecting cervical cancer. The SUVmax of cervical cancer lesions in ED phases was significantly higher than that of non-cancerous myometrium. A significant positive correlation was observed between the SUVmax of cervical cancer lesions at ED phases (80 seconds and 180-600 seconds) and SUVmax at WB F-FDG PET/CT (P < 0.05). The TBR at ED phases (120 seconds and 240-600 seconds) showed a significant positive correlation with TBR at WB F-FDG PET/CT (P < 0.05). Comparisons between stages T1 and T2 showed significantly higher SUVmax and TBR at various ED phases (300, 360, 480-600 seconds) and WB phase in stage T2 (P < 0.05).

[CONCLUSION] ED F-FDG PET/CT appears to have clinical value in diagnosing cervical cancer. The SUVmax and TBR obtained during the ED F-FDG PET/CT scan may help differentiate between stage T1 and stage T2 cervical cancer.

MeSH Terms

Humans; Female; Uterine Cervical Neoplasms; Fluorodeoxyglucose F18; Positron Emission Tomography Computed Tomography; Middle Aged; Radiopharmaceuticals; Aged; Adult; Neoplasm Staging; Sensitivity and Specificity

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