Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer.
1/5 보강
[BACKGROUND AND OBJECTIVE] The etiology of prostate cancer (PC) is multifactorial and poorly understood.
- p-value p = 0.04
- p-value p < 0.01
APA
Agrawal R, Al-Hiyari S, et al. (2025). Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer.. European urology oncology, 8(3), 716-730. https://doi.org/10.1016/j.euo.2024.10.015
MLA
Agrawal R, et al.. "Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer.." European urology oncology, vol. 8, no. 3, 2025, pp. 716-730.
PMID
39547899 ↗
Abstract 한글 요약
[BACKGROUND AND OBJECTIVE] The etiology of prostate cancer (PC) is multifactorial and poorly understood. It has been suggested that colibactin-producing Escherichia coli positive for the pathogenicity island pks (pks) initiate cancers via induction of genomic instability. In PC, androgens promote oncogenic translocations. Our aim was to investigate the association of pksE. coli with PC diagnosis and molecular architecture, and its relationship with androgens.
[METHODS] We quantified the association of pksE. coli with PC diagnosis in a volunteer-sampled 235-person cohort from two institutional practices (UT San Antonio). We then used colibactin 742 and DNA/RNA sequencing to evaluate the effects of colibactin 742, dihydrotestosterone (DHT), and their combination in vitro.
[KEY FINDINGS AND LIMITATIONS] Colibactin exposure was positively associated with PC diagnosis (p = 0.04) in our clinical cohort, and significantly increased replication fork stalling and fusions in vitro (p < 0.01). Combined in vitro exposure to colibactin 742 and DHT induced more somatic mutations of all types than exposure to either alone. The combination also elicited kataegis, with a higher density of somatic point mutations. Laboratory analyses were conducted using a single cell line, which limited our ability to fully recapitulate the complexity of PC etiology.
[CONCLUSIONS AND CLINICAL IMPLICATIONS] Our findings are consistent with synergistic induction of genome instability and kataegis by colibactin 742 and DHT in cell culture. Colibactin-producing pks E. coli may plausibly contribute to PC etiology.
[PATIENT SUMMARY] We investigated whether a bacterial toxin that is linked to colon cancer can also cause prostate cancer. Our results support this idea by showing a link between the toxin and prostate cancer diagnosis in a large patient population. We also found that this toxin causes genetic dysfunction in prostate cancer cells when combined with testosterone.
[METHODS] We quantified the association of pksE. coli with PC diagnosis in a volunteer-sampled 235-person cohort from two institutional practices (UT San Antonio). We then used colibactin 742 and DNA/RNA sequencing to evaluate the effects of colibactin 742, dihydrotestosterone (DHT), and their combination in vitro.
[KEY FINDINGS AND LIMITATIONS] Colibactin exposure was positively associated with PC diagnosis (p = 0.04) in our clinical cohort, and significantly increased replication fork stalling and fusions in vitro (p < 0.01). Combined in vitro exposure to colibactin 742 and DHT induced more somatic mutations of all types than exposure to either alone. The combination also elicited kataegis, with a higher density of somatic point mutations. Laboratory analyses were conducted using a single cell line, which limited our ability to fully recapitulate the complexity of PC etiology.
[CONCLUSIONS AND CLINICAL IMPLICATIONS] Our findings are consistent with synergistic induction of genome instability and kataegis by colibactin 742 and DHT in cell culture. Colibactin-producing pks E. coli may plausibly contribute to PC etiology.
[PATIENT SUMMARY] We investigated whether a bacterial toxin that is linked to colon cancer can also cause prostate cancer. Our results support this idea by showing a link between the toxin and prostate cancer diagnosis in a large patient population. We also found that this toxin causes genetic dysfunction in prostate cancer cells when combined with testosterone.
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