Potential impact of omentin-1 genetic variants on perineural invasion in prostate cancer.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: and without BCR
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Interestingly, the wild-type TT homozygous genotype was associated with significantly lower expression levels compared to the AA genotype of the rs2274907 variant. Additionally, mRNA levels were lower in PCa tissues compared to normal tissues, indicating that omentin-1 acts as a protective factor in PCa.
One of the most prevalent cancers and a major global cause of mortality in men is prostate cancer (PCa).
APA
Weng WC, Lin TH, et al. (2025). Potential impact of omentin-1 genetic variants on perineural invasion in prostate cancer.. Journal of Cancer, 16(12), 3767-3774. https://doi.org/10.7150/jca.119089
MLA
Weng WC, et al.. "Potential impact of omentin-1 genetic variants on perineural invasion in prostate cancer.." Journal of Cancer, vol. 16, no. 12, 2025, pp. 3767-3774.
PMID
40959111 ↗
Abstract 한글 요약
One of the most prevalent cancers and a major global cause of mortality in men is prostate cancer (PCa). Omentin-1, an adipokine, has been shown to play a protective role by reducing proinflammatory cytokine secretion. The relationships among carcinogenic lifestyle factors, biochemical recurrence (BCR), polymorphisms, and PCa remain unclear. We investigated the impact of clinicopathological features and four gene variants on PCa risk in 701 Taiwanese male patients with and without BCR. Compared with the TT genotype, the TA+AA genotypes of SNP rs2274907 were associated with a lower risk of perineural invasion. Similarly, the AG+GG genotypes of rs4656959 were associated with a lower risk of perineural invasion compared to the AA genotype. Importantly, PCa patients without BCR exhibited the same effects. Interestingly, the wild-type TT homozygous genotype was associated with significantly lower expression levels compared to the AA genotype of the rs2274907 variant. Additionally, mRNA levels were lower in PCa tissues compared to normal tissues, indicating that omentin-1 acts as a protective factor in PCa.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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