Association between serum uric acid and prostate cancer risk: The modifying role of genotype.
1/5 보강
[BACKGROUND] The role of uric acid in prostate cancer risk remains uncertain, with evidence suggesting both carcinogenic and protective effects.
- 95% CI 1.21-2.99
- HR 0.77
- 추적기간 29.7 years
APA
Chen R, Donlon TA, et al. (2025). Association between serum uric acid and prostate cancer risk: The modifying role of genotype.. Journal of clinical and translational research, 11(5), 96-105. https://doi.org/10.36922/jctr025260029
MLA
Chen R, et al.. "Association between serum uric acid and prostate cancer risk: The modifying role of genotype.." Journal of clinical and translational research, vol. 11, no. 5, 2025, pp. 96-105.
PMID
41377165 ↗
Abstract 한글 요약
[BACKGROUND] The role of uric acid in prostate cancer risk remains uncertain, with evidence suggesting both carcinogenic and protective effects. Genetic factors may be key modifiers of this association.
[OBJECTIVE] This study aimed to determine whether the relationship between uric acid and prostate cancer risk differs by the genotype of connective tissue growth factor ().
[METHODS] We examined 6,259 Japanese-American men in Hawaii, cancer-free at baseline (1965-1968, ages 45-68), who were followed for incident prostate cancer until 1999. Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL. genotypes were classified as common allele homozygotes (CC) or minor allele carriers (T). Cox proportional hazards models estimated hazard ratios (HRs), adjusting for age and potential confounders.
[RESULTS] During a median follow-up of 29.7 years, 285 prostate cancer cases were identified. A significant interaction between and hyperuricemia was observed. Among men with the - genotype, hyperuricemia was not associated with risk (HR = 0.77, 95% confidence interval [CI]: 0.51-1.17). In contrast, among - homozygotes, hyperuricemia was linked to a higher risk (HR = 1.91, 95% CI: 1.21-2.99). Men with both the - genotype and hyperuricemia had a higher risk (HR = 1.72, 95% CI: 1.17-2.54) compared with all other subjects.
[CONCLUSION] The association between uric acid and prostate cancer varied by genotype. Hyperuricemia increased risk among - homozygotes, whereas a nonsignificant protective effect was seen among allele carriers.
[RELEVANCE TO PATIENTS] Monitoring and lowering serum uric acid may help reduce prostate cancer risk in men with the - genotype.
[OBJECTIVE] This study aimed to determine whether the relationship between uric acid and prostate cancer risk differs by the genotype of connective tissue growth factor ().
[METHODS] We examined 6,259 Japanese-American men in Hawaii, cancer-free at baseline (1965-1968, ages 45-68), who were followed for incident prostate cancer until 1999. Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL. genotypes were classified as common allele homozygotes (CC) or minor allele carriers (T). Cox proportional hazards models estimated hazard ratios (HRs), adjusting for age and potential confounders.
[RESULTS] During a median follow-up of 29.7 years, 285 prostate cancer cases were identified. A significant interaction between and hyperuricemia was observed. Among men with the - genotype, hyperuricemia was not associated with risk (HR = 0.77, 95% confidence interval [CI]: 0.51-1.17). In contrast, among - homozygotes, hyperuricemia was linked to a higher risk (HR = 1.91, 95% CI: 1.21-2.99). Men with both the - genotype and hyperuricemia had a higher risk (HR = 1.72, 95% CI: 1.17-2.54) compared with all other subjects.
[CONCLUSION] The association between uric acid and prostate cancer varied by genotype. Hyperuricemia increased risk among - homozygotes, whereas a nonsignificant protective effect was seen among allele carriers.
[RELEVANCE TO PATIENTS] Monitoring and lowering serum uric acid may help reduce prostate cancer risk in men with the - genotype.
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