Hsa_circ_0030568 Promotes the Proliferation and Migration of Prostate Cancer Cells the miR-141-3p-BRD4 Axis.
[INTRODUCTION] Numerous studies have indicated that circular RNAs (circRNAs) play an important role in diverse cancers.
APA
Sun C, Xiang C, et al. (2026). Hsa_circ_0030568 Promotes the Proliferation and Migration of Prostate Cancer Cells the miR-141-3p-BRD4 Axis.. Combinatorial chemistry & high throughput screening, 29(2), 221-232. https://doi.org/10.2174/0113862073341224241228054703
MLA
Sun C, et al.. "Hsa_circ_0030568 Promotes the Proliferation and Migration of Prostate Cancer Cells the miR-141-3p-BRD4 Axis.." Combinatorial chemistry & high throughput screening, vol. 29, no. 2, 2026, pp. 221-232.
PMID
39901544
Abstract
[INTRODUCTION] Numerous studies have indicated that circular RNAs (circRNAs) play an important role in diverse cancers. However, the specific molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unclear.
[METHOD] In this study, we performed western blotting, real-time quantitative polymerase chain reaction, CCK-8 assay, cell scratch wound assay, and RNA immunoprecipitation assay.
[RESULTS] These results showed that the expression of hsa_circ_0030568 was remarkably increased in PCa cells by using quantitative real-time PCR combined with dataset analysis. Mechanistically, circ_0030568 could physically bind to miR-141-3p and elevate the expression of BRD4 via sponging miR-141-3p in PCa cells, then accelerating the progression of PCa. Upregulation of hsa_circ_0030568 induces tumor progression through the miR-141-3p-BRD4 axis.
[CONCLUSION] Taken together, these findings suggested that hsa_circ_0030568 may act as a potential biomarker of PCa and a promising target for PCa treatment.
[METHOD] In this study, we performed western blotting, real-time quantitative polymerase chain reaction, CCK-8 assay, cell scratch wound assay, and RNA immunoprecipitation assay.
[RESULTS] These results showed that the expression of hsa_circ_0030568 was remarkably increased in PCa cells by using quantitative real-time PCR combined with dataset analysis. Mechanistically, circ_0030568 could physically bind to miR-141-3p and elevate the expression of BRD4 via sponging miR-141-3p in PCa cells, then accelerating the progression of PCa. Upregulation of hsa_circ_0030568 induces tumor progression through the miR-141-3p-BRD4 axis.
[CONCLUSION] Taken together, these findings suggested that hsa_circ_0030568 may act as a potential biomarker of PCa and a promising target for PCa treatment.
MeSH Terms
MicroRNAs; Humans; Male; Prostatic Neoplasms; RNA, Circular; Cell Proliferation; Cell Movement; Cell Cycle Proteins; Transcription Factors; Cell Line, Tumor; Bromodomain Containing Proteins
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